In vitro activity of tigecycline against Brucella spp.

Amaç: Brucelloz tedavisinde tigesiklinin in vitro etkinliği ile ilgili bilgi çok fazla bulunmamaktadır. Çalışmamızda Brucella cinsi mikroorganizmalara karşı trimetoprim-sülfametaksazol, rifampisin, tetrasiklin, streptomisin ve siprofloksasin ile tigesiklinin in vitro aktivitesinin karşılaştırılması amaçlanmıştır. Çalışma Planı: Brucella cinsi 96 izolata karşı tigesiklin, trimetoprim-sülfametaksazol, rifampisin, tetrasiklin, streptomisin ve siprofloksasinin in vitro aktivitesi belirlenmiştir. Minimal inhibitör konsantrasyon (MİK) değerleri E-test yöntemiyle saptanmıştır. Bulgular: Tüm Brucella izolatlarına karşı en düşük MİK50 ve MİK90 değerleri tigesiklinde belirlenmiştir. Tigesiklinin en yüksek MİK değeri 0.19 µg/mL olarak saptanmıştır. Sonuç: Tetrasikline dirençli olan izolatlar da dahil olmak üzere Brucella izolatlarına karşı en düşük MİK değeri tigesiklin ile belirlenmiştir. Tigesiklinin tedavide kullanımı klinik çalışmalar ile onaylanmalıdır.

Anahtar Kelimeler:

Brucella, Bruselloz, Rifampin, Streptomisin, Siprofloksazin, Tetrasiklin, Trimetoprim-sulfametoksazol kombinasyonu

Tigesiklinin Brucella spp' ye karşı in vitro aktivitesi

Objectives: There are no published data regarding efficacy of tigecycline in brucellosis and in vitro data are scarce. We compared the in vitro activity of tigecycline to that of trimethoprim-sulfamethoxazole, rifampicin, tetracycline, streptomycin and ciprofloxacin against Brucella spp. Study Design: In vitro activities of tigecycline, trimethoprim-sulfamethoxazole, rifampicin, tetracycline, streptomycin and ciprofloxacin were evaluated against 96 strains of Brucella spp. Minimal inhibitory concentrations (MIC) were determined by the E-test method. Results: Tigecycline had low MIC50 and MIC90 values against all Brucella isolates; the highest MIC observed was 0.19 µg/mL. Conclusion: Tigecycline had low MICs against Brucella spp. including tetracycline-resistant isolates and its use in therapy should be confirmed by clinical studies.

Keywords:

Brucella, Brucellosis, Rifampin, Streptomycin, Ciprofloxacin, Tetracycline, Trimethoprim-Sulfamethoxazole Combination,

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