Hüseyin AYDIN, Adnan KARAİBRAHİMOĞLU, Abdulkerim SALKACI

KRONİK BÖBREK YETMEZLİĞİNDE HASTALIK SÜRESİ VE DİABETES MELLİTUSUN, RENAL PARANKİM DİFÜZYON MRI SİNYALLERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Amaç Kronik böbrek yetmezliğinde (KBY), renal parankimin difüzyon ağırlıklı (DW) magnetik rezonans görüntüleme (MRI) ADC değerlerinde azalma olduğu bilinmektedir. Ancak KBY hastalık süresinin renal ADC değerlerine olan etkisi bilinmemektedir. Bu çalışmada KBY hastalık süresi ve eşlik eden diabetes mellitusun (DM) renal parankimal ADC değerlerine olan etkisi araştırılmıştır. Gereç ve Yöntem Bu çalışmada 39 KBY ve eGFR’si normal sınırlarda 30 DM hastası ile 59 kişiden oluşan kontrol grubunun abdominal MR tetkikleri, retrospektif olarak değerlendirildi. KBY hastaları, hastalık süresine göre üç gruba ayrıldı (10< ve >10) ve eGFR’ye göre 1-5 olarak evrelendirildi. ADC ölçümleri, fokal küçük bir alan ve tüm parankimi içeren, iki farklı yöntem ile yapıldı. Bulgular KBY hastalık süresi, DM varlığı, insülin kullanımı ve dializ durumuna göre istatistiksel analize tabi tutularak değerlendirildi. Bulgular ADC değerleri KBY hastalarında, evre 2’den itibaren kontrol gurubuna göre anlamlı şekilde düşük (p0.05), sağlıklı grupta tüm parankimi içeren ROI ölçümleri, istatistiksel olarak anlamlı derecede düşük izlenmiştir (p

EVALUATION OF DISEASE DURATION AND EFFECT OF DIABETES MELLITUS ON RENAL PARENCHYMAL DIFFUSION MRI SIGNALS IN PATIENTS WITH CHRONIC RENAL FAILURE

ObjectiveIt is known that in chronic renal failure (CRF), diffusionweighted (DW) magnetic resonance imaging (MRI)ADC values of the renal parenchyma are reduced. However, the effect of CRF disease duration on renalADC values is unknown. In this study, the effect ofCRF disease duration and accompanying DM on renalparenchymal ADC values was investigated.Materials and MethodsIn this study, abdominal MR examinations of 39 CRFand 30 DM patients (eGFR within normal limits) and59 control subjects were evaluated retrospectively.CRF patients were divided into three groups accordingto disease duration (>5, 5-10, and >10) andwere staged as 1-5 according to the eGFR results.ADC measurements were made by two different methods,including a focal small area and the entire parenchyma.The findings were evaluated by statisticalanalysis according to the duration of CRF, presenceof DM, insulin use and dialysis status.ResultsADC values were significantly lower in CRF patientscompared to the control group since stage 2 (p 0.05), ROI measurements containing theentire parenchyma in the healthy group were statisticallysignificantly lower (p

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