Geriatrik Hastalarda Nöroonkolojik Sorunlar (Geriatrik Nöroonkoloji)

Dünya popülasyonu giderek yaşlanmakta ve bununla orantılı olarak bu yaşgrubunda görülen hastalıkların insidans ve prevalansı artmaktadır. Özelliklebu yaş grubunda görülen nöroonkolojik hastalıklar kanser metastazları veglioblastomdur. Eşlik eden başka hastalıkların olması, kullanılan ilaçların yanetkileri ve uygulananan tedavi yöntemlerine bağlı gelişebilen komplikasyonlar,bu grup hastalarda tedavi planlamasını zorlaştırmakta, morbidite/mortaliteoranlarının artmasına neden olmaktadır. Hastalarda yaşam kalitesini vefonksiyonel bütünlüğü bozmadan en uygun tedavinin seçilebilmesi için öncedenvar olan ve sonradan eklenebilecek sorunların multidisipliner olarakdeğerlendirilmesi önemlidir.

Neurooncological Problems in Geriatric Patients (Geriatric Neurooncology)

World human population is getting older and according to this, the incidence– prevalance of the diseases in this age group is increasing. Neurooncological diseases, especially seen in this age group are metastasis and glioblastoma. Comorbidities, therapy-related side effects and complications of the treatment modalities make the management difficult, and also increase the ratio of mobridity/ mortality. It is important to evaluate the problems in multidisciplinary process, to choose the best treatment modality without effecting the quality of life and functional independence

___

  • Pallis AG, Fortpied C, Wedding U, et al. EORTC elderly task force position paper: Approach to the older cancer patient. Eur J Cancer 2010;46 (9):1502- 1513
  • Decoster L, Van Puyvelde K, Mohile S, Wedding U, Basso U, Colloca G et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 2015;26(2):288-300
  • Cloney M, D’Amico R, Lebovic J, Nazarian M, Zacharia BE, Sisti MB, Bruce JN, McKhann GM, Iwamoto FM, Sonabend AM. Frailty in geriatric glioblastoma patients: a predictor of operative morbidity and outcome. World Neurosurgery 2016;89:362-367
  • Gehring K, Patwardhan SY, Collins R et al. A randomized trial on the efficacy of mthylphenidate and modafinil for improving cognitive functioning and symptoms in patients with primary brain tumor. J Neurooncol 2012;107:165-174
  • Perez-Larraya JG, Delattre JY. Treating glioblastoma in the elderly. CNS Oncol 2012;1:193-201
  • Minniti G, Lanzetta G, Scaringi C, Caporello P, Salvati M, Arcella A, et al. Phase II study of short- course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma. Int J Radiat Oncol Biol Phys. 2012;83(1):93-9.
  • Wick W, Platten M, Meisner C, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012;13(7):707- 715
  • Malmstrom A, Gronberg BH, Marosi C, et al. Temozolomide versus standart 6-week radiotherapy versus hypofractioned radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomized, phase 3 trial. Lancet Oncol. 2012;13 (9):916-926
  • Kono M, Arakawa Y, Mineharu Y, Ohka F, Kinoshita M, Nakae S, Miyashita K, Luchi T, Hirose Y, Natsume A. et al. P09.50 Phase I tial of temozolomide plus bevacizumab for newly diagnosed high-grade gliomas in the elderly: Interim report. Neuro-Oncology 2017;19(3):81
  • Holdhoff M, Chamberlain MC. Controversies in the treatment of elderly patients with newly diagnosed glioblastoma. J Natl Compr Canc Netw. 2013;11(9):1165- 1173
  • Perez-Larraya, Ducray F, Chinot O, Thomas IC, Taillandier L, Guillamo JS et al. Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial. Journal of Clınıcal Oncology 2011;29 (22):3050-3055
  • Roa W, Brasher PM, Bauman G, et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol. 2004;22(9):1583-1588
  • Stupp R, Mason WP, van den Bert MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996
  • Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 1994;12:627-42
  • D’Amico RS, Cloney MB, Sonabend AM, Zacharia B, Nazarian MN, Iwamoto FM, Sisti MB, Bruce JN, McKhann GM. The safety of surgery in elderly p a - tients with primary and recurrent glioblastoma. World Neurosurgery 2015;84(4):913- 919
  • Chaichana KL, Garzon_Muvdi T, Parker S et al. Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients. Ann Surg Oncol 2011;18:239-245
  • Laigle-Donadey F, Sanson M. Pattern of care of high-grade gliomas. Rev Prat 2006;56:1779-1786
  • Johans SJ, Garst JR, Burkett DJ, Grahnke K, Martin B, Ibrahim TFm Anderson DE, Prabhu VC. Identification of preoperative and intraoperative risk factors for complications in the elderly undergoing elective craniotomy. World Neurosurgery 2017;107:216-225
  • Fujita T, Sakurai K. Multivariate analysis of risk factors for postoperative pneumonia. Am J Surg 1995;169:304-307.
  • Karkouri K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, Mc Cluskey SA, et al. The independent association of massive blood loss with mortality in cardiac surgey. Transfusion 2004;44:1453- 1462.
  • Khaldi A, Helo N, Schneck MJ, Origitano TC. Venous thromboembolism: deep venous thrombosis and pulmonary embolism in a neurosurgical population. J neurosurg 2011;114:40-46
  • Oh T, Safaee M, Sun MZ, Garcia RM, Mc Dermott MW, Parsa AT, et al. Surgical risk factors for post-operative pneumonia following meningioma resection. Clin Neurol Neurosurg 2014;118:76-79.
  • Waterhouse E, Towne A. Seizures in the elderly: Nuances in presentation and treatment. Cleve Clin J Med 2005;72(suppl 3):S26-S37
  • Arif H, Buchsbaum R, Pierro J et al. Comparative effectiveness of 10 antiepileptic drugs in older adults witj epilepsy. Arch Neurol 2010;67:408-415
  • Drappatz J, Schiff D, Kesari S, et al. Medical management of brain tumor patients. Neurol Clin 2007;25:1035-1071
  • Hegi ME, Diserens A-C, Gorlia T, et al. MGMT Gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352(10):997- 1003 16. Perez-Larraya JG, Delattre JY. Management of elderly patients with gliomas. The Oncologist 2014;19:1258-1267
  • Bauchet L, Zouaoui S, Darlix A, Champfleur NM, Ferreira E, Fabbro M, Kerr C, Taillandier L. Assessment and treatment relevance in elderly glioblastoma patients. Neuro-Oncology 2014;16 (11):1459-1468
  • Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res. 2013;19(4):764-772
  • McDonald KL, McDonnell J, Muntoni A, et al. Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival. J Neuropathol Exp Neurol. 2010;69(7):729-736
  • Batchelor TT, Betensky RA, Esposito JM, et al. Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res. 2004;10(1 Pt 1):228-233
  • Chargari C, Feuvret L, Bauduceau O, et al. Treatment of elderly patients with glioblastoma: From clinical evidence to molecular highlights. Cancer Treat Rev. 2012;38(8):988-995
  • Pruitt AA. Medical management of patients with brain tumors. Curr Treat Options Neurol 2011;13:413-426.
  • Dolecek TA, Propp JM, Stroup NE, et al. CBTRUS statistical report: primary brain and central nervoussystem tumors diagnosed in the United States in 2005-2009. Neuro-Oncol. 2012;14 (5):v1-v49
  • Weller M, Platten M, Roth P, Wick W. Geriatric neuro-oncology: from mythology to biology. Neurology 2011;24:599-604
  • Loh D, Hogg F, Edwards P, MacColl J,Brogna C,- Bhangoo R. Two year experience of multi- disciplinary team (MDT) outcomes for brain metastases in a tertiary neuro-oncology centre. British J of Neurosurgery, 2017;https:// doi.org/10.1080/02688697.2017.1368449
  • Janelsins MC, Kohli S, Mohile SG, Usuki K, Ahles TA, Morrow GR. An update on cancer and chemotherapy related cognitive dysfunction:current status. Semin Oncol 2011;38(3):431-438
  • Delafuente JC. The silver tsunami is coming: Will pharmacy be swept away with the tide? Am J Pharm Educ 2009;73:1
  • Morioka T, Miyazaki H, Tsuruta K. Problems in neurosurgical operations on elderly patients-from the viewpoint of Anesthesiology. Neurol Med Chir (Tokyo) 1980;20:713-720
  • (http://www.tuik.gov.tr;08.07.2010) Saglik Bakanligi 2010 yili istatistikleri- Saglik Bakanligi Yayinlari, 2010;Ankara
  • Aboderin IA, Beard JR. Older people’s health in sub-Saharan Africa. Lancet. 2015; Feb 14;385 (9968):e9-11
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 1300-7416
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1994
  • Yayıncı: SDÜ Basımevi / Isparta
Sayıdaki Diğer Makaleler

Hemostatik Ajan Olarak Kullanılan Mecsina Hemostopper©, Ankaferd Blood Stopper® ve Traneksamik Asidin İmmunolojik Farklılıklarının Hücre Kültürü Çalışması ile Araştırılması

Mehmet Kemal TUMER, Mustafa CICEK

15-35 Yaş Arası Güney Türk Popülasyonunda Gömülü Diş Sıklığının Değerlendirilmesi: Epidemiyolojik Çalışma

İbrahim Şevki BAYRAKDAR, Hümeyra TERCANLI ALKIŞ, Sevcihan Günen YILMAZ, Büşra TANRIKOL

Investigation of Immunological Differences in Mecsina Hemostopper©, Ankaferd Blood Stopper® and Tranexamic Acid Used as Haemostatic Agents with Cell Culture Study

MEHMET KEMAL TÜMER, Mustafa ÇİÇEK

Aşırı Doz Siklopentolat Göz Damlasına Bağlı Gelişen Santral Antikolinerjik Sendrom

Mehmet Barış ÜÇER, Hülya Gökmen SOYSAL

Nadir Görülen Bir Akut Karın Olgusu: İdiopatik Omental İnfarkt

Halil İbrahim TAŞCI

Tiroid Karsinomu Olgularında İnce İğne Aspirasyonu Bulguları

Perihan UDUL, FİGEN BARUT, Şükrü Oğuz ÖZDAMAR

Evaluation Of The Incidence Of Impacted Tooth In Southern Turkish Populatıon Aged Between 15 And 35 Years: An Epidemiological Study

SEVCİHAN GÜNEN YILMAZ, İBRAHİM ŞEVKİ BAYRAKDAR, HÜMEYRA TERCANLI ALKIŞ, Büşra TANRIKOL

Gömülü 3. Molar Di̇şleri̇n Operati̇f Zorluk Skoruna ve Kompli̇kasyonlara Göre Değerlendi̇ri̇lmesi

NESRİN SARUHAN

Süleyman Demirel Üniversitesi Tıp Fakültesi Dönem-3 Öğrencilerinin Farmakoloji Eğitimine Etki Eden Faktörlerin İncelenmesi

MEHTAP SAVRAN, HALİL AŞCI, Mekin SEZİK, YONCA SÖNMEZ

Yükselmi̇ş Kan Eozi̇nofi̇l Sayısı Canlı Veri̇ci̇li̇ Karaci̇ğer Transplantasyonu Sonrası Geç Ortaya Çıkan Akut Rejeksi̇yonun (GOAR) Tahmi̇ni̇nde Önemli̇ Bi̇r Beli̇rteç Olabilir mi ?

MÜCAHİT ÖZBİLGİN, TUFAN EGELİ, TARKAN ÜNEK, CİHAN AĞALAR, Alikadir DEĞİRMENCİ, İbrahim ASTARCIOĞLU, Sevda ÖZKARDEŞLER, Özgül SAĞOL, HÜLYA ELLİDOKUZ