Fatih BAYGUTALP, Duygu ALTINTAŞ, Ayhan KUL

FREQUENCY OF IRON DEFICIENCY AND IRON DEFICIENCY ANEMIA IN FIBROMYALGIA SYNDROME

ObjectiveFibromyalgia syndrome (FMS), which is a chronicpain condition of unknown etiology, is mainly characterized by widespread pain, sleep disturbances,memory problems, and fatigue, which seriously impair quality of life. Decreased production of biogenicamine neurotransmitters as a result of decreasediron levels in the blood may play a role in the pathophysiology of FMS. This study aimed to investigatethe prevalence of iron-deficiency and iron-deficiencyanemia in patients with FMS and to draw attentionto the prevalence of iron-deficiency in patients withFMS. Material and MethodsThe patients who applied to the physical medicine andrehabilitation outpatient clinic of our hospital in the lastfive years, who were diagnosed as FMS and whoseserum ferritin, total iron-binding capacity (TIBC), vitamin B12 concentrations and plasma hemoglobinconcentrations were determined were analyzed retrospectively. Data were analyzed by using SPSS 23package program.ResultsIn the independent group comparisons between female and male patients with FMS, both plasma hemoglobin and serum iron levels were significantly lower infemale patients than in male patients (p =0.009 and p= 0.002, respectively). There were no statistically significant differences between serum vitamin B12 levelsand serum ferritin levels between male and femalepatients with FMS (p= 0.344, p=0,093 respectively).Besides, iron-deficiency and iron-deficiency anemiawere observed in 28% and 12% of all FMS patients,respectively.ConclusionMeasuring serum ferritin levels in FMS patients andtreating iron-deficiency when necessary is recommended to increase the success of FMS treatment.Keywords: ferritin, fibromyalgia syndrome, frequency,iron-deficiency

FİBROMİYALJİ SENDROMUNDA DEMİR EKSİKLİĞİ VE DEMİR EKSİKLİĞİ ANEMİSİ GÖRÜLME SIKLIĞI

Amaç Etiyolojisi tam olarak bilinmeyen kronik bir ağrı durumu olan fibromiyalji sendromu (FMS) temel olarak yaygın ağrı, uyku bozuklukları, hafıza sorunları ve yaşam kalitesini ciddi şekilde bozan yorgunluk ile karakterizedir. Kandaki azalmış demir seviyelerinin bir sonucu olarak biyojenik amin nörotransmiterlerinin üretimindeki azalma FMS'nin patofizyolojisinde rol oynayabilir. Bu çalışmada FMS'li hastalarda demir eksikliği ve demir eksikliği anemisinin prevalansının araştırılması ve FMS'li hastalarda demir eksikliği prevalansına dikkat çekilmesi amaçlanmıştır. Gereç ve Yöntem Hastanemiz fiziksel tip ve rehabilitasyon polikliniği’ne son beş yıl içinde müracaat eden hastalardan FMS tanısı alan ve serum ferritin, total demir bağlama kapasitesi (TDBK),vitamin B12 konstantrasyonları ile plazma hemoglobin konstantrasyonları belirlenmiş olan hastalar retrospektif olarak değerlendirilmiştir. Veriler SPSS 23 paket programı kullanılarak analiz edilmiştir. Bulgular FMS'li kadın ve erkek hastalar arasındaki bağımsız grup karşılaştırmalarında, plazma hemoglobin ve serum demir düzeylerinin kadın hastalarda erkek hastalara göre anlamlı derecede düşük olduğu görülmüştür (sırasıyla, p = 0.009 ve p = 0.002). FMS'li erkek ve kadın hastalar arasında serum B12 düzeyleri ile serum ferritin düzeyleri arasında istatistiksel olarak anlamlı bir fark görülmemiştir (sırasıyla p = 0.344, p = 0,093). Ayrıca, tüm FMS hastalarının % 28’inde demir eksikliği ve% 12'sinde demir eksikliği anemisi olduğu belirlenmiştir. Sonuç FMS tedavisinde başarının artırılması için FMS hastalarında serum ferritin seviyelerinin ölçülmesi ve gerektiğinde demir eksikliğinin tedavi edilmesi önerilmektedir.

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