Erdoğan OKUR, Mehmet Emre SİVRİCE, Hasan YASAN, Mustafa TÜZ, Vural AKIN, Deniz DİLEK

ADENOİDEKTOMİ YAPILAN HASTALARDA PLATELET-LENFOSİT ORANI

Amaç Bu çalışmada adenoidektomi hastalarında platelet- lenfosit oranının (PLO) prediktif bir faktör olup olmadığının ve adenoid hipertrofisi olan hastalarda platelet-lenfosit oranının sistemik inflamasyonu gösterip göstermediğinin ortaya konulması amaçlandı. Gereç ve Yöntem Çalışma grubuna Süleyman Demirel Üniversitesi Kulak Burun Boğaz Anabilim Dalı’nda (KBB) 2017- 2018 yılları arasında adenoid hipertrofisi tanısı alan 3-11 yaşları arasında toplam 100 erkek hasta dahil edilmiştir. Kontrol grubu, Üroloji ve Çocuk Cerrahisi kliniklerinde sünnet edilen 100 sağlıklı erkekten oluşmaktaydı. Hastaların tıbbi kayıtları retrospektif olarak incelendi. Preoperatif laboratuvar parametreleri hasta dosyaları gözden geçirilerek değerlendirildi. Platelet- lenfosit oranı mutlak platelet sayısının mutlak lenfosit sayısına bölünmesi ile elde edildi. Bulgular Platelet-lenfosit oranı kontrol ve çalışma grupları için sırasıyla 91,68 ve 84,15 idi ve aradaki fark istatistiksel olarak anlamlı değildi (Mann-Whitney U testi, p=0,062). Mann-Whitney U testi ile WBC, platelet ve lenfosit sayıları değerlendirildiğinde çalışma ve kontrol grupları arasında anlamlı bir fark izlenmedi. (p>0,05). Kontrol grubunda platelet-lenfosit oranı, çalışma grubuna göre daha yüksekti. Sonuç Platelet ve lenfosit standart sapmalarının çok yüksek olduğunu gözlemledik, bu nedenle adenoidektomide platelet-lenfosit oranının güvenilir bir değer olmadığı kanaatine varıldı.

PLATELET-TO-LYMPHOCYTE (PLR) RATIOS IN ADENOIDECTOMY PATIENTS

ObjectiveThe aim of this study is to investigate Platelet-to-lymphocyte(PLR) ratios in children operated for adenoidhypertrophyto determine whether this ratio can be apossible predictive factor in adenoidectomy. We alsoaimed to investigate whether PLR can help indicateongoing systemic inflammation on patients with adenoidhypertrophy.Materials and MethodsOne hundred boys aged 3-11 years, who had undergoneadenoidectomy for adenoid hypertrophybetween 2017 and 2018 at Suleyman Demirel University,Department of Ear Nose and Throat (ENT),were assigned to the study group. The control is 100healthy boys who had been circumcised in the Urologyor Pediatric Surgery Departments. Patients medicalrecords were retrospectively reviewed. The results of preoperative complete blood counts were evaluatedby reviewing the patient files. We calculated thePLR value by dividing platelet count with lymphocytecount.ResultsPLR were 91,68 and 84,15 for control and studygroups respectively and the difference was not statisticallysignificant (Mann-Whitney U test, p = 0.062).The Mann-Whitney U test showed no significant differencebetween study and control groups amongWBC, platelet and lymphocyte counts (p >0.05). PLRof the control group was greater than the study group.ConclusionWe observed platelet and lymphocyte standard deviationsare too high, therefore we beleive that PLR is nota reliable value in adenoidectomy

PDF

___

1. Korkmaz M, Korkmaz H, Küçüker F, Ayyıldız SN, Çankaya S. Evaluation of the Association of Sleep Apnea-Related Systemic Inflammation with CRP, ESR, and Neutrophil-to-Lymphocyte Ratio. Medical Science Monitor. 2015;21:477-481.
2. Kiliçkaya M, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. International Journal of Otolaryngology. 2015;2015:1-4.
3. Atan D, Ozcan KM, Koseoglu S, Ikinciogullari A, Cetin MA, Ensari S, et al. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. The Turkish Journal of Ear Nose and Throat. 2015;25(2):97- 101.
4. Kilickaya MM, Aynali G, Tuz M, Bagci O. Is There A Systemıc Inflammatory Effect of Cholesteatoma?. International Archives of Otorhinolaryngology. 2016;21(01):42-45.
5. Şentürk M, Azgın İ, Övet G, Alataş N, Ağırgöl B, Yılmaz E. The role of the mean platelet volume and neutrophil-to-lymphocyte ratio in peritonsillar abscesses. Brazilian Journal of Otorhinolaryngology. 2016;82(6):662-667.
6. Ulu S, Ulu M, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil- to-Lymphocyte Ratio as a New, Quick, and Reliable Indicator for Predicting Diagnosis and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. Otology & Neurotology. 2013;34(8):1400-1404.
7. Derin S, Erdogan S, Sahan M, Topal H, Sozen H. Neutrophil– Lymphocyte Ratio in Patients with Adenoidectomy. Journal of Clinical and Diagnostic Research. 2016;10(3):3-5
8. Tamhane U, Aneja S, Montgomery D, Rogers E, Eagle K, Gurm H. Association Between Admission Neutrophil to Lymphocyte Ratio and Outcomes in Patients With Acute Coronary Syndrome. The American Journal of Cardiology. 2008;102(6):653-657.
9. Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L et al. Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction. The American Journal of Cardiology. 2008;101(6):747- 752.
10. Acharya S, Rai P, Hallikeri K, Anehosur V, Kale J. Preoperative platelet lymphocyte ratio is superior to neutrophil lymphocyte ratio to be used as predictive marker for lymph node metastasis in oral squamous cell carcinoma. Journal of Investigative and Clinical Dentistry. 2016;8(3):e12219.
11. Ozturk K, Akyildiz N, Uslu M, Gode S, Uluoz U. The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer. European Archives of Oto-Rhino-Laryngology. 2016;273(12):4425- 4429.
12. Karadeniz G, Aktoğu S, Erer O, Kır S, Doruk S, Demir M et al. Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. Biomarkers in Medicine. 2016;10(7):701-710.
13. Karatas MB, Ipek G, Onuk T, Gungor B, Durmus G, Canga Y, et al. Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism. Acta Cardiologica Sinica. 2016;32(3):313- 20.
14. Liu W, Lin S, Wang L, Fang C, Lin Y, Braddock M et al. Platelet- to- Lymphocyte Ratio: A Novel Prognostic Factor for Prediction of 90-day Outcomes in Critically Ill Patients With Diabetic Ketoacidosis. Medicine. 2016;95(4):1-7.
15. You J, Zhu G, Xie L, Liu W, Shi L, Wang O et al. Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget. 2016;7(18):1-12.