Vitamin D ile Koroner Kollateral Seviyesi Arasındaki İlişki

Amaç: Literatürde koroner kollateral dolaşımın (KKD) derecesi ile D vitamini seviyesi arasında muhtemel bir ilişki olabileceğine dair yayınlar mevcuttur. Bu çalışmanın amacı kronik total oklüzyon (KTO) nedeniyle perkütan koroner girişim yapılan hastalarda hem Rentrop hem de Werner sınıflandırmasına göre KKD ile D vitamini seviyesi arasında bir ilişki olup olmadığının araştırılmasıdır. Materyal-Metot: Mevcut çalışma tek-merkezli, retrospektif kohort çalışmasıdır. KTO işlemi için hastaneye yatırılan ardışık 101 hasta çalışmaya alınmıştır. Hastalar KKD derecesine göre hem Rentrop hem de Werner sınıflandırmasına göre üçer gruba ayrılmıştır. Her bir grup 25(OH)VitD3 seviyesine göre birbiriyle kıyaslanmıştır. Bulgular: Hastalar Rentrop sınıflandırmasına göre üç gruba ayrıldığında gruplar arasında 25(OH)VitD3 seviyesi açısından fark saptanmamıştır [Rentrop 1: 15,7 ng/ml (7,0-77,0 ng/ ml), Rentrop 2: 16,9 ng/ml (7,0-71,3), Rentrop 3: 16,6 ng/ ml (7,0-28,7), p=0,925]. Hastalar Werner sınıflandırmasına göre tekrar üç gruba sınıflandırıldığında yine gruplar arasında 25(OH)VitD3 seviyesi açısından fark saptanmamıştır [Werner 0: 19,6 ng/ml (7,0-77,0 ng/ml), Werner 1: 16,6 ng/ml (7,0- 71,3), Werner 2: 17,0 ng/ml (7,0-28,3), p=0,411]. Sonuç: Çalışma sonucuna göre 25(OH)VitD3 seviyesi ile KKD derecesi arasında klinik pratikte bire bir ilişki olmadığı kanaatindeyiz.

The Relation Between The Grade of Coronary Collaterals and Vitamin D Levels

Objective: There have been studies which revealed a possiblerelation with the grade of coronary collateral circulation (CCC)and the level of Vitamin D in the literature. The objective ofthis study was to assess whether there is a correlation betweenthe grade of CCC and the level of Vitamin D according to bothRentrop and Werner classifications in patients with coronarychronic total occlusion (CTO) who underwent percutaneouscoronary intervention.Material-Method: The present study is a single-centre,retrospective cohort study. A total of 101 consecutive patients,who were hospitalized to undergo coronary CTO procedure, wereenrolled in the study. The patients were classified into 3 groupswith regard to the grade of CCC according to both Rentrop andWerner classifications. These groups were compared with eachother according to the 25(OH)VitD3 levels.Results: There was no significant difference among 3 groupswith regard to 25(OH)VitD3 levels when the patients wereclassified according to the Rentrop classification [Rentrop 1:15.7 ng/ml (7.0-77.0 ng/ml), Rentrop 2: 16.9 ng/ml (7.0-71.3),Rentrop 3: 16.6 ng/ml (7.0-28.7), p=0.925]. Moreover, therewas no significant difference among 3 groups with regardto 25(OH)VitD3 levels when the patients were classifiedaccording to the Werner classification. [Werner 0: 19.6 ng/ml(7.0-77.0 ng/ml), Werner 1: 16.6 ng/ml (7.0-71.3), Werner 2:17.0 ng/ml (7.0-28.3), p=0.411].Conclusions: We deem that there may not be a direct correlation(one-to-one relationship) between the level of 25(OH)VitD3 andthe grade of CCC in clinical practice.

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