ATALAY DOĞRU, Osman Erhan AKCAN, MEHMET ŞAHİN

Psöriatik Artrit Hastalarında Metabolik Değişiklikler

Amaç: Psöriatik Artrit (PsA), psöriazis ile ilişkili inflamatuvar bir artrittir. PsA'daki kronik inflamasyonun aterogenez ve periferik insülin direncine yol açtığı, dolayısıyla hipertansiyon ve tip 2 diyabetes mellitus gelişiminde rol oynadığı öne sürülmektedir. Çalışmamızda PsA hastalarında ortaya çıkan metabolik değişiklikleri değerlendirmeyi amaçladık. Materyal-Method: Çalışmaya 32 PsA hastası ve yaş-cinsiyet olarak benzer, herhangi bir romatizmal hastalığı olmayan 32 sağlıklı kontrol dahil edildi. Hastaların yaş, cinsiyet, fizik muayene ile cilt ve eklem değerlendirmeleri, hastalık aktivite skorları, bel çevresi, kan basıncı ve vücut kitle indeksi (VKİ) ölçümleri, laboratuar verileri ile tedavi için kullanılan ilaçlar kaydedildi. Insulin direnci ölçümü için Homeostaz Model Değerlendirilmesi - İnsulin Direnci (HOMA - IR) İndeksi kullanıldı. Bulgular: Çalışmamızda PsA hastalarında kontrol grubuna kıyasla trigliserid, sistolik ve diyastolik kan basıncı ve bel çevresi değerlerinde istatistiksel olarak anlamlı yükseklik saptandı. HOMA-IR değeri ve insülin direnci olan hasta sayısı açısından iki grup arasında anlamlı fark görülmedi. Hastalık aktivite skorları, eklem tutulum paterni ile metabolik parametreler arasında istatistiksel olarak anlamlı ilişki tespit edilmedi.Sonuç: PsA hastalarının takiplerinde sadece aktivasyon parametrelerinin değil metabolik parametrelerinin de dikkatle taranması gerekmektedir. PsA'nın sadece cilt ve eklemi tutan bir hastalık olmadığı sistemik birçok özelliğinin olduğu akılda bulundurulmalı ve hastalar metabolik parametrelerde ortaya çıkacak bozukluklar acısından sorgulanmalı ve araştırılmalıdır.

Metabolic Parameters In Patients With Psoriatic Arthritis

Objective: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. It is suggested that chronic inflammation in PsA leads to atherogenesis and peripheral insulin resistance, thus playing a role in the development of hypertension and type 2 diabetes mellitus. In our study, we aim to evaluate the metabolic parameters in patients with PsA. Material-Method: In our study, we included 26 psoriatic arthritis and 26 peoIn our study, we included 32 psoriatic arthritis and 32 person similar in age and sex without any rheumatic disease who were admitted to Rheumatology outpatient centre. Patients' age, gender, physical examination and skin-joint evaluations, disease activity scores, waist circumference, blood pressure, body mass index (BMI) measurements, laboratory data, and medications used for treatment were recorded. HOMA - IR (Homeostasis Model Assessment - Insulin Resistance) Index was used for insulin resistance measurement.Results: In our study, triglyceride, systolic and diastolic blood pressures and waist circumference values were significantly higher in PsA patients compared to the control group. There was no significant difference between the two groups in terms of HOMA-IR value and number of patients with insulin resistance. There was no statistically significant correlation between disease activity scores, joint involvement pattern and metabolic parameters.Conclusions: Not only the disease activity score but also the metabolic parameters should be carefully screened in patient with PsA. It should be borne in mind that PsA has many systemic features and metabolic parameters should also be evaluated in detail.

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