Yaşlı Kadınlarda Polifarmasi ve Komorbiditeler

Amaç: Bu çalışmanın amacı 65 yaş ve üzerindekikadınlarda polifarmasi görülme sıklığının ve ilişkilikomorbiditelerin belirlenmesidir.Gereç ve Yöntem: Tanımlayıcı tipteki bu araştırmaHaziran 2014 tarihinde Çorum ilinde yapıldı.Araştırmanın örneklemini 65 yaş ve üzerindeki 260kadın oluşturdu. Araştırmanın verileri katılımcılarınsosyo-demografik özelliklerini, sağlık ve hastalıkdurumlarını ve ilaç kullanım davranışlarınısorgulayan 30 maddelik bir anket formu iletoplandı. Bulgular: Bu çalışmada yaşlı kadınlarda polifarmasisıklığı %53.8 olarak bulundu. Bu çalışmada kronikhastalık sayısı beş ve üzerinde olanlarda, ilaçlarınınyan etkileri hakkında bilgilendirilenlerde, ilaçlarınınyan etkisi ile karşılaşanlarda, kullanılmayan ilaçlarıçevresindekilere veren yaşlı kadınlarda polifarmasisıklığı anlamlı ölçüde yüksek bulundu. Polifarmasiriskinin 3-4 kronik hastalığı olanlarda 2.14 kat, 5 veüzerinde olanlarda 5.17 kat, doktoru tarafındanilaçlarının yan etkisi hakkında bilgilendirilenlerde2.31 kat daha yüksek olduğu belirlendi.Sonuç: Bu çalışmada yaşlı kadınlarda polifarmasininyaygın bir sorun olduğu belirlendi. Yaşlı bireylerdepolifarmasinin önüne geçilmesi; birinci basamaktakronik hastalıklarda akılcı ilaç kullanımına yöneliksağlık eğitimlerinin artırılması ile mümkün olabilir.

Polypharmacy and Comorbidities among Elderly Women

Aim: The aim of this study was to determine theprevalence of polypharmacy and associatedcomorbidities among women aged 65>= years.Materials and Method: This descriptive study wasconducted during June 2014 in Çorum. The sampleof the study was composed of 260 women aged65>= years. The data were collected using a 30 itemquestionnaire asking questions about sociodemographic characteristics, health and diseasestatus and medication use of the participants.Findings: In this study, the prevalence ofpolypharmacy among the elderly women was foundto be 53.8%. The prevalence was significantlyhigher among those with 5 or more chronic diseasesand among those who have been informed on sideeffects of the medications, who have experiencedthe side effects of the medications and among theelderly women giving unused medications to peoplearound them. It was seen that the risk ofpolypharmacy was 2.14 times, 5.17 times and 2.31times higher among those with 3-4 chronic diseases,with 5 or more chronic diseases and those beinginformed on the side effects of the medications,respectively.Conclusion: In the study, it was determined thatpolypharmacy was a common problem amongelderly women. Polypharmacy in elderly can beprevented by promoting health education programsin primary care on rational use of medications forchronic diseases.

___

  • 1.United Nations (UN). World Population Prospects: The 2012 Revision: United Nations Population Division. Accessed June 21, 2014, at http://esa.un.org/ wpp/Excel-Data /population. htm
  • 2. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States--the Slone Survey. JAMA 2002; 287(3): 337-44.
  • 3. Bushardt RL, Massey EB, Simpson TW, Ariail JC, Simpson KN. Polypharmacy: Misleading, but manageable. Clin Interv Aging 2008; 3(2): 383-89.
  • 4. Lapi F, Pozzi C, Mazzaglia G, Ungar A, Fumagalli S, Marchionni N, Geppetti P, Mugelli A, Di Bari M. Epidemiology of suboptimal prescribing in older, community dwellers: a two wave, population based survey in Dicomano, Italy. Drugs Aging 2009; 26: 1029-38.
  • 5. Jyrkka¨ J, Enlund H, Korhonen MJ, Sulkava R, Hartikainen S. Polypharmacy status as an indicator of mortality in an elderly population. Drugs Aging 2009; 26: 1039-48.
  • 6. Jyrkka¨ J, Enlund H, Korhonen MJ, Sulkava R, Hartikainen S. Patterns of drug use and factors associated with polypharmacy and excessive polypharmacy in elderly persons. Drugs Aging 2009; 26: 493-503.
  • 7. Azad N, Tierney M, Victor G, Kumar P. Adverse drug events in the elderly population admitted to a tertiary care hospital. J Healthc Manag 2002; 47: 295-306.
  • 8. Hanlon JT, Lindblad C, Hajjar ER, McCarthy TC. Update on drug-related problems in the elderly. Am J Geriatr Pharmacother 2003; 1(1): 38-43.
  • 9. Turkish Statistical Institute. Elderly With Statistics 2013. Cited 2014 June 21. Available from: http://www.tuik.gov.tr/PreHaber Bultenleri. do?id=16057.
  • 10. World Health Organization (WHO). World Health Statistics 2014. Accessed June 21, 2014, at http://www.who.int/gho/publications/World_ health_statistics / 2014 /en /.
  • 11. Davise AM. Psychogeriatric report of a WHO Scientific Group, Technical Reports Series 507. Epidemiology 1972; 14(1): 9-21.
  • 12.Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L. Aging with multimorbidity: A systematic review of the literature. Ageing Res Rev 2011; 10(4):430-39.
  • 13.Carvalho MF, Romano-Lieber NS, BergstenMendes G, Secoli SR, Ribeiro E, Lebrão ML, De Oliveira Duarte YA. Polypharmacy among the elderly in the city of São Paulo, Brazil-SABE Study. Rev Bras Epidemiol 2012; 15(4): 817-827.
  • 14.Lai SW, Liao KF, Liao CC, Muo CH, Liu CS, Sung FC. Polypharmacy correlates with increased risk for hip fracture in the elderly. Medicine 2010; 89: 295-99.
  • 15.Taşkın Şayir Ç, Aslan Karaoğlu S, Evcik Toprak D. Aile Hekimliği Polikliniği'ne başvuran 65 yaş üstü hastalarda polifarmasi ve tamamlayıcı tedavi kullanımlarının değerlendirilmesi. Türk Aile Hekimliği Dergisi 2014; 18(1): 35-41.
  • 16. Çakmur H. Türkiye'nin İki Farklı İlinde (Kars-İzmir) Yaşlılarda Polifarmasiyi Etkileyen Faktörler. Türkiye Klinikleri Tıp Bilimleri Dergisi 2014; 34(1): 71-80.
  • 17.Masoodi NA. Polypharmacy: To err is human, to correct divine. BJMP 2008; 1(1):6-9.
  • 18. Sato I, Akazawa M. Polypharmacy and adverse drug reactions in Japanese elderly taking antihypertensives: a retrospective database study. Drug Healthc Patient Saf 2013; 5: 150.
  • 19. Junius Walker U, Theile G, Hummers-Pradier E. Prevalence and predictors of polypharmacy among older primary care patients in Germany. Fam Pract 2007; 24: 4-19.
  • 20.Rozenfeld S, Fonseca MJM, Acurcio FA. Drug utilization and polypharmacy among the elderly: a survey in Rio de Janeiro City, Brazil. Rev Panam Salud Publica 2008;23(1): 34-43.
  • 21. Vyas A, Pan X, Sambamoorthi U. Chronic condition clusters and polypharmacy among adults. Int J Family Med 2012; 2012: 1-8. 22.Kim HA, Shin JY, Kim MH, Park BJ. Prevalence and Predictors of Polypharmacy among Korean Elderly. PLoS ONE 2014; 9(6): 1-7.
  • 23.Nobili A, Garattini S, Mannucci PM. Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium. Journal of Comorbidity 2011; 1: 28-44.
  • 24.Pan HH, Li CY, Chen TJ, Su TP, Wanget KY. Association of polypharmacy with fall-related fractures in older Taiwanese people: age- and gender-specific analyses. BMJ Open 2014; 4: 1-7.
  • 25. Crentsil V, Ricks MO, Xue QL, Fried LP. A pharmacoepidemiologic study of communitydwelling, disabled older women: factors associated with medication use. Am J Geriatr Pharmacother 2010; 8(3): 215-224.