Hidroksizin Hidroklorürün Memeli Makrofajları Üzerindeki Etkilerinin İncelenmesi

Amaç: Hidroksizin hidroklorür son yıllarda anksiyete bozukluğu, ruhsal sıkıntı ve gerginliğin tedavisinde yaygın olarak tercih edilen antihistaminik türevli bir ilaçtır. Literatürde Hidroksizin hidroklorürün bağışıklık sistemi üzerine etkileri ile ilgili yeterli çalışma mevcut değildir. Gereç ve Yöntemler: Çalışmamızda J774.2 makrofaj hücre hattında lipopolisakkarit (LPS) tehlike sinyali varlığında ve yokluğunda 1, 5,10 ve 20 µg/ml hidroksizin hidroklorür uygulayarak proinflamatuvar sitokin seviyelerine etkilerini araştırdık. İstatistiksel analiz için Student t testi uygulandı (p

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Sakarya Tıp Dergisi-Cover
  • Başlangıç: 2011
  • Yayıncı: Sakarya Üniversitesi
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