Selim Kutlu, Zafer Sahin, Aynur Koc, Raviye Ozen Koca, Alpaslan Ozkurkculer, Pinar Cakan, Z. Isik Solak Gormus

Dişi Sıçanlarda Üç Farklı Stres Modelinin Anksiyete ve Depresyon Benzeri Davranışlara Etkilerinin Karşılaştırılması

Amaç Mevcut çalışmada yetişkin dişi sıçanlarda üç farklı stres protokolünün anksiyete/depresyon benzeri davranışlara etkisinin kıyaslanması amaçlanmıştır. ( Sakarya Tıp Dergisi 2019, 9(1):131-140 ). Gereç ve Yöntemler Yetişkin Wistar sıçanlar kontrol, immobilizasyon stresi-1 (günlük 45 dakika) immobilizasyon stresi-2 (günlük iki kez 45 dakika) ve sosyal izolasyon (metabolik kafeste) olarak rastgele dört gruba ayrıldı (n=8/grup). Stres protokolleri 10 gün boyunca uygulandı ve anksiyete ve depresyonla ilişkili davranışlar, hayvanlar diöstrüs dönemindeyken, açık alan ve zorunlu yüzme testi ile değerlendirildi. Anksiyete ve depresyon testleri 10 günlük dinlenme süresinden sonra tekrarlandı. Bulgular Açık alan testinde, merkez alanda geçirilen zaman immobilizasyon stresi-2 ve sosyal izolasyon gruplarında azaldı (p

Comparison of Effects of Three Distinct Stress Models on Anxiety- and Depression-Related Behaviors in Female Rats

Objective The aim of the present study was to compare the effects of three distinct stress protocols on anxiety/depression-related behaviors in adult female rats.( Sakarya Med J 2019, 9(1):131-140 )Materialsand MethodsAdult Wistar rats were randomly divided into four groups (n=8/ group) as control, immobilization stress-1 (daily 45 minutes) immobilization stress-2 (daily twice 45minutes) and social isolation (rats were housed in a metabolic cage). Stress protocols were performed for a period of 10 days. When the animals were in diestrus, anxiety anddepression-like behaviors were evaluated by the open field test and forced swimming test, respectively. Anxiety and depression tests were repeated after a 10-day rest period.Results In the open field test, a percentage of time spent in the central area was lower in the immobilization stress-2 and social isolation (p

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