PERİODONTAL HASTALIK, ATEROSKLEROZ VE OKSİDATİF STRES İLİŞKİSİ: DERLEME

Peridontal hastalıklar dişin destek dokularında enflasyonla ve yıkımla karakterize enfeksiyöz hastalıklardır. Periodontal hastalığın ilerlemesinde, bakteriyel kolonizasyona karşı gelişen immünolojik reaksiyonlar önemli rol oynamaktadır. Periodontal hastalıklar ile kardiovasküler hastalıkların temel etkeni olan ateroskleroz arasındaki direk nedensel ilişki tam olarak belirlenememesine karşın, her iki hastalığı ilişkilendiren farklı patolojik mekanizmalar ve ortak risk faktörleri mevcuttur. Aterosklerotik plakların periodontal patojenlerle enfeksiyonu, periodontal enflamasyonun kronik sistemik enflamasyon yoluyla aterojenik etki oluşturması her iki hastalığın olası ilişkisini açıklayan olası mekanizmalardandır. Serbest radikaller ile koruyucu antioksidan sistem arasındaki dengenin bozulması sonucu meydana gelen oksidatif stresin, son yıllarda her iki hastalığın başlaması ve ilerlemesiyle ilişkili enflamatuar bir belirteç olduğu üzerinde durulmaktadır. Bu derlemede periodontal hastalık, ateroskleroz ve oksidatif stres arasındaki ilişkinin ele alınması amaçlanmıştır.

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Sağlık Bilimleri Dergisi-Cover
  • ISSN: 1018-3655
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1993
  • Yayıncı: Prof.Dr. Aykut ÖZDARENDELİ
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