Mehmet Burak Özkan, Ulaş Emre Akbulut, İshak Abdurrahman Işık, Atike Atalay

Kronik aktif gastritli çocuklarda çölyak arter kan akımının değerlendirilmesi

Amaç: Kronik gastritli çocuklarda mide kan akımı hakkında bilgi bulunmamaktadır. Bu çalışmada kronik gastritli çocuklarda transabdominal dupleks Doppler ultrasonografi ile çölyak arterin hemodinamik değişikliklerini değerlendirmeyi amaçladık. Gereç ve yöntem: Kronik aktif gastritli (endoskopi ve histoloji tanısı alan) 36 çocuğu (grup 1) ve 28 asemptomatik sağlıklı çocuğu (grup 2) dupleks Doppler ultrasonografi ile inceledik. Kronik gastritli çocuklar Helicobacter pylori enfeksiyonunun varlığına ve inflamasyonun şiddetine göre tekrar sınıflandırıldı. Çölyak arterin uç diyastolik hızı, ortalama pik sistolik hızı, pulsatilite indeksi ve rezistif indeksi karşılaştırıldı. Bulgular: Grup 1'de ortalama pulsatilite indeksi ve ortalama rezistif indeksi anlamlı olarak daha yüksekken (p

Evaluation of celiac artery blood flow in children with chronic active gastritis

Purpose: Knowledge on gastric blood flow in children with chronic gastritis is scarce. In this study, we aimedto evaluate hemodynamic changes of the celiac artery (CA), in children with chronic gastritis assessed usingtrans-abdominal duplex Doppler ultrasonography.Materials and methods: We examined 36 children (group 1) with chronic active gastritis (diagnosed byendoscopy and histology) and 28 asymptomatic control children (group 2) with duplex Doppler ultrasonography.Children with chronic gastritis were classified again according to the severity of inflammation and the presenceof Helicobacter pylori infection. Mean peak systolic velocity (PSV), enddiastolic velocity (EDV), resistive index(RI), and pulsatility index (PI) of the CA were compared.Results: The mean PSV and the mean EDV were significantly lower in patients than in controls (p

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1. Sierra D, Wood M, Kolli S, Felipez LM. Pediatric gastritis, gastropathy, and peptic ulcer disease. Pediatr Rev 2018;39:542-549. https://doi.org/10.1542/ pir.2017-0234
2. Lee EJ, Lee YJ, Park JH. Usefulness of ultrasonography in the diagnosis of Peptic ulcer disease in children. Pediatr Gastroenterol Hepatol Nutr 2019;22:57-62. https://doi.org/10.5223/pghn.2019.22.1.57
3. Akbulut UE, Emeksiz HC, Kocak FG, Livaoglu A. Diagnostic yield of esophagogastroduodenoscopy in children with chronic abdominal pain. Arch Med Sci 2018;14:74-80. https://doi.org/10.5114/ aoms.2017.67675
4. Thomson M, Tringali A, Dumonceau JM, et al. Paediatric gastrointestinal endoscopy: European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines. J Pediatr Gastroenterol Nutr 2017;64:133- 153. https://doi.org/10.1097/MPG.0000000000001408
5. Whittle BJ. The defensive role played by gastric microcirculation. Meth Find Exp Clin Pharmacol 1989;11:35-43.
6. Guslandi M. Mucosal blood flow and gastric protectioneffect of neurohormonal and pharmacological agents. Int J Clin Pharmacol Ther Toxicol 1986;24:143-147.
7. Guslandi M, Sorghi M, Tittobello A. Does Helicobacter pylori affect gastric microcirculation? Ital J Gastroenterol 1994;26:383-384.
8. Koktener A, Turkay FGC, Erarslan E, et al. Doppler sonography of hemodynamic changes of the celiac artery in chronic active gastritis. Turk J Med Sci 2012;42:1273-1277. https://doi.org/10.3906/sag-1201- 8
9. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-1181. https://doi. org/10.1097/00000478-199610000-00001
10. Tytgat GNJ. The sydney system: endoscopic division. Endoscopic appearances in gastritis/duodenitis. J Gastroenterol Hepatol 1991;6:223-234. https://doi. org/10.1111/j.1440-1746.1991.tb01469.x
11. Wang Y, Yuan SY, Zhang ZY. A study of gastric mucosal blood flow of peptic ulcer, chronic gastritis and gastric carcinoma. Zhonhua Nei Ke Za Zhi 1993;32:239-242.
12. Henriksnas J, Atuma C, Phillipson M, Sandler S, Engstrand L, Holm L. Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse. World J Gastroenterol 2009;15:219-225. https://doi.org/10.3748/wjg.15.219
13. Moorchung N, Srivastava AN, Gupta NK, Malaviya AK, Achyut BR, Mittal B. The role of mast cells and eosinophils in chronic gastritis. Clin Exp Med 2006;6:107-114. https://doi.org/10.1007/s10238-006- 0104-9
14. Caruso RA, Parisi A, Crisafulli C, et al. Intraepithelial infiltration by mast cells in human Helicobacter pylori active gastritis. Ultrastruct Pathol 2011;35:251-255. https://doi.org/10.3109/01913123.2011.606964
15. Hu Y, Liu JP, Zhu Y, Lu NH. The ımportance of toll-like receptors in NF-κB signaling pathway activation by Helicobacter pylori ınfection and the regulators of this response. Helicobacter 2016;21:428-440. https://doi. org/10.1111/hel.12292
16. Rahmani A, Moradkhani A, Ahmadi MRH, et al. Association between serum levels of high sensitive C-reactive protein and inflammation activity in chronic gastritis patients. Scand J Gastroenterol 2016;51:531- 537. https://doi.org/10.3109/00365521.2015.1102318
17. GimbroneJr MA, García Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res 2016;118:620-636. https://doi.org/10.1161/ CIRCRESAHA.115.306301
18. Judaki A, Norozi S, Ahmadi MRH, Ghavam SM, Asadollahi K, Rahmani A. Flow mediated dilation and carotid intima media thickness in patients with chronic gastritis associated with Helicobacter pylori infection. Arq Gastroenterol 2017;54:300-304. https://doi. org/10.1590/S0004-2803.201700000-39
19. Lee M, Baek H, Park JS, et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: a crosssectional study. PLoS One 2018;13:e0193646. https:// doi.org/10.1371/journal.pone.0193646
20. Atuma C, Engstrand L, Holm L. Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and plateletactivating factor receptor-dependent pathway in rats. Scand J Gastroenterol 1999;34:1183-1189. https://doi. org/10.1080/003655299750024689