Ayse AYZİT KİLİNC, Gulizar ALİSHBAYLİ, Nursena KOLOĞLU, Haluk ÇOKUĞRAŞ

Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with noncystic fibrosis bronchiectasis

Purpose: Non- cyctic fibrosis bronchiectasis (non-CFBE) is a chronic inflammatory lung disease which causes significant morbidity in children. Exacerbations in non-CFBE are associated with worsening lung function. Several laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested to be as an indicator in various chronic inflammatory diseases. We aimed to asses the value of the NLR, PLR and MPV as markers of acute exacerbation in pediatric patients with non-CFBE. Materials and methods: The NLR, PLR, and MPV values of 55 non-CFBE patients (during exacerbation and stable state periods) and 79 healthy control subjects were analyzed. Results: The mean ages for the patient and control group were 13.62±3.5 and 12.72±2.68 years, respectively. 64% of patients and 54% of control subjects were male. The white blood cell count, absolute neutrophil count, and NLR values were significantly higher in the exacerbation group than in the healthy control group (p

Nötrofil-lenfosit oranı ve trombosit-lenfosit oranlarının çocuklardaki kistik fibroz dışı bronşektazinin akut alevlenmesinde potansiyel biyolojik gösterge olarak değerlendirmesi

Amaç: Kistik fibroz dışı bronsektazi (KFDBE) çocuklarda önemli morbiditeye yol açan kronik inflamatuar akciğer hastalığıdır. KFDBE'de alevlenme akciğer fonksiyonlarının kötüye gitmesi ile ilişkilidir. Nötrofillenfosit oranı (NLO), trombosit- lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) gibi bazı laboratuar parametrelerinin çesitli kronik inflamatuar hastalıkları için bir gösterge olduğu öne sürülmüştür. Çalışmamızda, KFDBE’li çocuklardaki akut alevlenmede NLO, TLO ve OTH ölçümlerinin bir gösterge olarak değerlendirilmesini amaçladık. Gereç ve yöntem: Çalışmada, akut alevlenme ve stabil dönemdeki 55 KFDBE' li hastanın ve 79 sağlıklı kontrol grubunun NLO, TLO ve OTH değerleri analiz edildi. Bulgular: Çalışma ve kontrol grubundaki hastaların ortalama yaşları sırasıyla 13,62±3,5 ve 12,72±2,68 yıldı. Çalışma grubunun %64'ü ve kontrol grubunun %54'ü erkekti. Alevlenme dönemindeki grupta beyaz küre sayısı, nötrofil oranı ve NLO değerleri sağlıklı kontrol grubundan anlamlı olarak yüksekti (p

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