Ümit ÇABUŞ, Babür KALELİ, İbrahim Veysel FENKCİ, İlknur KALELİ, Suleyman DEMİR

Polikistik over sendrom'lu hastalarda Pancreatic derived factor ve Malondialdehit düzeylerinin incelenmesi

Amaç: β hücrelerinin fonksiyonlarındaki değişiklikler polikistik over sendromunun (PCOS) patogenezinde önemli roller oynayabilir. Pankreatic Derived Factor (PANDER), patolojik koşullar altında pankreatik β hücre apoptozunu indükleyen sitokin benzeri bir proteindir. Bu araştırma, serum PANDER düzeylerini belirlemek ve serum PANDER düzeylerinin oksidatif stres ve PCOS'taki insülin direnci ile ilişkili olup olmadığını belirlemek için planlanmıştır. Gereç ve Yöntem: Bu kontrollü klinik çalışmada PKOS tanısı almış 27 hasta ve 24 sağlıklı kadın control grubu olarak değerlendirildi. Serum lipit alt fraksiyonları, açlık glikozu, insülin, gonadotropinler ve androjenler, malondialdehit (MDA) ve PANDER düzeyleri ölçüldü. İnsülin direncini tahmin etmek için homeostaz model değerlendirmesi (HOMA-IR) kullanıldı. Bulgular: Çalışma ve kontrol grubundaki denekler bel ölçümleri, gonadotropinler, lipit alt fraksiyonları, MDA ve PANDER düzeyleri açısından benzerdi, PKOS'lu kadınlar sağlıklı kadınlardan önemli ölçüde daha yüksek FAI ve HOMA-IR'ye sahipti. Serum PANDER düzeyleri çalışılan parametrelerle ilişkili değildi. Sonuç: Bu sonuçlar PANDER seviyesinin PCOS'ta insülin direnci, over kaynaklı hiperandrojenizm ve oksidatif stres ile ilişkili olmadığını göstermiştir.

Anahtar Kelimeler:

PCOS, PANDER, MDA

The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome

Purpose: Alterations in β-cell function may play crucial roles in the pathogenesis of polycystic ovary syndrome (PCOS). Pancreatic-derived factor (PANDER) is a cytokine-like protein, inducing of pancreatic β-cell apoptosis under pathological conditions. This investigation was planned to determine serum PANDER levels and establish whether serum PANDER levels are related with oxidative stress, and insulin resistance in PCOS. Materials and Methods: Twenty-seven patients with PCOS and 24 healthy control women were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin, gonadotropins, androgens, malondialdehyde (MDA) and PANDER levels were measured. Homeostasis model assessment (HOMA-IR) were used to estimate insulin resistance. Results: Subjects in study and control groups were similar with respect to waist measurements, gonadotropins, lipid sub-fractions, MDA and PANDER levels, the women with PCOS had considerably higher FAI and HOMA-IR than healthy women. Serum PANDER levels were not correlated with any studied parameters. Conclusion: These outcomes showed that PANDER level is not related with insulin resistance, ovarian hyperandrogenism and oxidative stress in PCOS.

Keywords:

PCOS PANDER, MDA, Insulin Resistance,

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