Yumurta allerjisi olan çocuklarda kızamık-kızamıkçık-kabakulak aşılaması sonrası reaksiyon durumunun değerlendirilmesi

Amaç: Yumurta alerjisi olan çocuklara içerisinde yumurta proteini bulunan kızamık-kızamıkçık-kabakulak (KKK) aşısının doğrudan uygulanması önerilmesine rağmen hekimler genellikle çekince yaşamakta, bu durum hekim ve ailelerde sıkıntılara yol açmaktadır. Bu çalışmamızda, kliniğimizde yumurta alerjisi nedeniyle izlenen hastalarda, KKK aşısı sonrası aşı reaksiyon sıklığının değerlendirilmesi amaçlanmıştır. Yöntem: Kliniğimizde yumurta alerjisi tanısı ile izlenen hastaların Ocak 2019-Ocak 2020 tarihleri arasında KKK aşı kayıtları incelendi. KKK aşısı yapılan hastaların demografik ve klinik özellikleri, laboratuvar bulguları değerlendirildi. Bulgular: Tanı anında yaş ortalaması 6,1±2,7 ay olan 80 hastanın %62,5’i (n=50) erkek idi. Hastaların %68,8’inde (n=55) atopik dermatit, %18,8’inde (n=15) ürtiker- anjioödem, %25’inde (n=20) reaktif hava yolu hastalığı, %15’inde (n=12) anafilaksi, %16,3’ünde (n=13) proktokolit mevcuttu. Tüm hastalara KKK aşısı aşı ile test yapılmadan, tek dozda uygulandı. Bir hastada aşıdan 30 dakika sonra aşırı ağlama, huzursuzluk ve yüzde kızarıklık şeklinde reaksiyon gözlenirken antihistaminik sonrası 1 saat içinde şikayetleri geriledi. Diğer hastalarda izlemlerinde sorun yaşanmadı. Sonuç: Yumurta alerjili hastalarda KKK aşısı sonrası herhangi bir ciddi reaksiyon gözlenmemiştir. Bağışıklama ve yapılma zamanı önemli olması nedeniyle yumurta alerjisi olan hastalarda KKK aşısının güvenle yapılabileceğini düşünüyoruz. Ancak aşı yapılan merkezlerde olası reaksiyonlara müdahale edilebilir uygun koşullar sağlanmalı ve aşı sonrası hastalar uygun süre gözlem altında bulundurulmalıdır.

Anahtar Kelimeler:

çocuk, yumurta alllerjisi, kızamık-kızamıkçık-kabakulak aşılama

The evaluation of allergic reaction in children with egg allergy after measles-mumps-rubella vaccination

Objective: Although direct administration of the measles -mumps -rubella (MMR) vaccine which contains egg protein is recommended to children with egg allergy, physicians often have reservations, this situation leads to problems in physicians and families. In this study, we aimed to evaluate the frequency of reaction after the MMR vaccine in patients who were monitored for egg allergy in our clinic. Methods: MMR vaccination records were examined between January 2019 and January 2020 of patients diagnosed with egg allergy in our clinic. Demographic and clinical characteristics, laboratory findings were evaluated in patients vaccinated with MMR Results: The average age was 6.1±2.7 months, and 62.5% (n=50) of the cases were male. According to their diagnostic distribution, the patients had atopic dermatitis (n=55; 68.8%), urticaria (n=15; 18.8%), reactive airway disease (n=20; 25%), proctocolitis (n=13; 16.3%) and anaphylaxis (n=12; 15%). A whole dose of vaccine was administered to all cases. Flushing and crying was observed in one patient 30 minutes after vaccination, while her complaints resolved 1hour after antihistamine. No problems were observed in the follow-up of other patients. There was no severe side effect in any of the cases. Conclusion: No serious reactions have been observed in patients with egg allergy after the MMR vaccine. We believe that the MMR vaccine can be safely administered in patients with egg allergy in vaccinated centers, as immunization and delivery time are important. However, appropriate conditions can be intervened in possible reactions and patients should be kept under observation for the appropriate period after vaccination.

Keywords:

children, egg allergy, measles-mumps-rubella vaccination,

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