Although the medical schools created by the Ottoman government played an important role in the introduction of European medical knowledge to the Ottoman Empire, the individualistic initiatives should not be ignored. Medical journals published in various languages in various cities of the empire, helped the transmission of novelties in medicine from European literature. About 15 medical journals in French saw the press in Turkey during the second half of the 19th century and early 20th century. Among them, La Revue médico-pharmaceutique edited and published by the French pharmacist Pierre Apéry (1852-1918) in Istanbul was a long-lasting journal with its 27 volumes dating from 1888 to 1914. By examining the first volume of the journal, the present work aims to expose the medical and pharmaceutical knowledge transmitted through the excerpts, articles and news borrowed to European sources and the peculiarities of the transmission.