Erdal BODAKÇI, Nazife BİLGE, Ersoy ACER, Deniz ARIK, Timuçin KAŞİFOĞLU

Hidroksiklorokinin tetiklediği akut generalize ekzantematöz püstülozis: Literatür eşliğinde bir olgu

Akut generalize ekzantematöz püstülozis (AGEP), genel olarak ilaç ilişkili bir reaksiyon olup, ödemli eritem zemininde akut gelişen, folliküler olmayan, steril püstüller ile karakterize bir tablodur. Hidroksiklorokin (HCQ), antimalaryal bir ilaç olup romatizmal ve dermatolojik hastalıkların tedavisinde yaygın olarak kullanılmaktadır ve AGEP’in nadir nedenlerinden biridir. 44 yaşında kadın hasta romatoid artrit nedenli hidroksiklorokin alırken gelişen AGEP, HCQ’nin kesilmesi ve steroid tedavisinin başlanması ile düzeldi. Bu olgudaki amacımız romatoloji pratiğinde sık kullanılan bir ilaç olan HCQ kullanımı sonrası gelişebilecek oldukça nadir istenmeyen bir durum olan AGEP ile ilişkili farkındalığı arttırmak ve bu istenmeyen etkinin yönetimini belirlemek.

Anahtar Kelimeler:

Akut generalize ekzantematöz püstülozis

Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine: Case Report and a Review of the Literature

Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is generally drug induced and characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) is an antimalarial drug which is widely used in dermatologic and rheumatologic diseases and reported as a rare cause of AGEP. A 44 years old female patient developed AGEP while recieving HCQ for rheumatoid arthritis and resolved after cessation of HCQ and starting steroid therapy. The aim of this case is to raise the awareness about AGEP which is an uncommon and undesired effect of HCQ; a widely used drug in rheumatology practice.

Keywords:

Acute generalized exanthematous pustulosis,

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