Aşı İ mmü nitesi ve Yanıtını Etkileyen Faktö rler

Aşılama en etkin ve güvenilir tıbbi uygulamalardan birisidir, her yıl milyonlarca yaşamı kurtarır. Aşılara karşı oluşturduğumuz yanıt aşıya, aşılanan bireye ve sağlık sistemine ait faktörlerden etkilenir. Aşılara nasıl yanıt verdiğimizi ve bu yanıta etki edebilecek, sık karşılaşılan durumları bilmek bireylerin aşı yanıtlarındaki farklılıkları değerlendirmemize yardımcı olacaktır.

Vaccine İ mmünity and Factörs Assöciated with Respönse tö Vaccines

Vaccination is one of the most effective and safe medical interventions that saves millions of lives each year. The immune response to vaccines is influenced by the factors such as the properties of the vaccine, the recipient of the vaccine, and the health care system. Knowing how we respond to vaccines and the factors that influence this response may help us in evaluating individual differences in vaccine immunity.

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1. Furman D, Davis MM. New approaches into understanding the immune response to infection and immunization. Vaccine. 2015;33:5271-81
2. Claire Anne Sieglist. Vaccine immunology. Plotkin SA, Orenstein WA, Offit PA (Eds) In Plotkin’s Vaccines; 6th ed; 2013, Elsevier Saunders: Pp 16-34.
3. Pulendran B. Systems vaccinology: probing humanity’s diverse immune systems with vaccines. Proc Natl Acad Sci USA. 2014;111:12300-306
4. Vetter V, Denizer G, Friedland LR, Krishnan J, Shapiro M. Understanding modern-day vaccines: what you need to know. Ann Med. 2018;50:110- 20.
5. Sánchez-Ramón S, Conejero L, Netea MG, Sancho D, Palomares Ó, Subiza JL. Trained immunity-based vaccines: a new paradigm for the development of broad-spectrum anti-infectious formulations. Front Immunol. 2018;9:2936.
6. Di Pasquale A, Preiss S, Tavares Da Silva F, Garçon N. Vaccine adjuvants: from1920 to 2015 and beyond. Vaccines (Basel) 2015;3:320–43
7. Bunker JJ, Bundelac A. IgA responses to microbiota. Immunity. 2018;49:211–24.
8. Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol 2011;12:509-17.
9. Hibbs BF, Miller ER, Shimabukuro T. Notes from the Field: Rotavirus Vaccine Administration Errors — United States, 2006–2013. MMWR 2014;63:81-81
10. CDC. Suboptimal response to hepatitis B vaccine given by injection into the buttock. MMWR 1985;34:105-8.
11. Shaw FE, Jr., Guess HA, Roets JM, et al. Effect of anatomic injection site, age and smoking on the immune response to hepatitis B vaccination. Vaccine 1989;7:425-30.
12. 12. Laupèze B, Hervé C, Di Pasquale A, Tavares Da Silva F. Adjuvant Systems for vaccines: 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood. Vaccine. 2019;37:5670-80.
13. 13. Garçon N, Di Pasquale A. From discovery to licensure, the Adjuvant Systemstory. Hum Vaccin Immunother 2017;13:19–33.
14. 14. Reed SG, Bertholet S, Coler RN, Friede M. New horizons in adjuvants for vaccine development. Trends Immunol. 2009;30:23-32.
15. 15. Crooke SN, Ovsyannikova IG, Poland GA, Kennedy RB. Immunosenescence and human vaccine immune responses. Immun Ageing. 2019;16:25.
16. 16. Whittaker E, Goldblatt D, McIntyre P, Levy O. Neonatal immunization: rationale, current state, and future prospects. Fron Immunol. 2018;9:532.
17. 17. Zimmerman P, Curtis N. Factors that influence the immune response to vaccination. Clin Microbiol Rev 2019;32:e00084-18.
18. 18. Wiedermann U, Garner-Spitzer E, Wagner A. Primary vaccine failure to routine vaccines: Why and what to do? Hum Vaccin Immunother. 2016;12:239-43.
19. 19. Young KM, Gray CM, Bekker LG. Is obesity a risk factor for vaccine non-responsiveness? PLoS One 2013;8:e82779