Psoriazis'li hastalarda kalsipotriol ve metilprednizolon aseponat topikal tedavilerinin klinik değerlendirilmesi

İnflamatuar ve proliferatif deri hastalıklarının tedavisinde kortikosteroidlerin başarısı bu alanda yeni kortikosteroidlerin geliştirilmesine yol açmıştır. Fakat bu ilaçların özellikle uzun süreli kullanımı istenmeyen etkilere yol açabilir. Metilprednizolon aseponat (MPA) yeni geliştirilmiş bir kortikosteroiddir. Kalsipotriol ise hafif ve orta şiddetteki kronik plak psoriazislilerde etkinliği kanıtlanmış yeni vitamin D analoğudur. Bu çalışmada vücutlarının en az %5'ini kapsayan, stabil plak tip psoriazisi olan toplam 30 kişiden oluşan iki ayrı hasta grubunda, topikal kalsipotriol ile MPA tedavilerinin klinik değerlendirilmesi yapıldı. Kremler tüm lezyonlara sabah akşam şeklinde 8 hafta süreyle uygulanılırken, skalp, yüz ve anogenital bölgedeki lezyonlar çalışmaya dahil edilmedi. Hastaların doktor kontrolü dışında başka bir topikal tedavi uygulamalarına izin verilmedi. Hastalık şiddeti tedavi öncesi ve sonrası psoriasis alan şiddet indeksi (PASI) skoru ile değerlendirildi. Sonuç olarak kalsipotriol'un metilprednizolon aseponat kadar plak tip psoriazisde etkili ve iyi tolere edilebilen bir ilaç olduğu kanısına varıldı.

Anahtar Kelimeler:

Psoriyazis, Metilprednizolon, İlaç uygulama, topikal, İlaç tepkisizliği, İlaç tedavisi, Kalsitriol, İlaç uygulama programı

The clinical assessment of calcipotriol and methylprednisolone ointments in the treatment of Psoriasis vulgaris

The success of corticosteroids in the therapy of inflammatory and proliferative disorders of the skin has led to vigorous development of new corticosteroids. The development of more potent corticosteroids has extended their usefulness in a wide variety of skin diseases, but especially with long term use, has led to unwanted effects. Methyl Prednisolone Aceponale (MPA) is a new corticosteroid diester developed for the topical treatment of steroid-responsive skin diseases. Calcipotriol is a new vitamin D analogue, which has proved a very effective topical treatment for mild to moderate chronic plaque psoriasis. Thirty patients with stable plaque psoriasis involving at least 5% of their body surface area were recruited. This trial compared Calcipotriol with MPA ointment. The ointments were applied to all the lesions twice daily over a period of 8 weeks, apart from those on the scalp, face and anogenital region. No other treatment was permitted. The severity of the disease was evaluated in the pre-and post-treatment cases according to PASI scores. Calcipotriol ointment was as effective as Methylprednisolone aceponate ointment as measured by the PASI in patients with stable plaque psoriasis. Both treatments were well tolerated.

Keywords:

Psoriasis, Methylprednisolone, Administration, Topical, Drug Tolerance, Drug Therapy, Calcitriol, Drug Administration Schedule,

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