Halise ÇIKMAN, İsmail İŞLEK, Murat AYDIN, Abdülkerim BEDİR, Kemal BAYSAL, Şükrü KÜÇÜKÖDÜK

İnsüline bağımlı diyabetes mellituslu çocuklarda serum lipoprotein ve apolipoprotein düzeyleri

Ondokuz Mayıs Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları kliniğinde 1-9 yıl süreyle izlenmekte olan 32 insüline bağımlı diyabetes mellitus (İDMM)'lu çocukta serum lipid ve lipoprotein düzeyleri ile idrarda albumin incelenerek 30 sağlıklı çocuktan oluşan kontrol grubuyla karşılaştırıldı. Klinik takibi 1-5 yıl olan 22 hasta grup 1'i, izlem süresi 5 yıl üzerinde olan 10 hasta da grup 2'yi oluşturdu. Her iki grupta 3'er olguda (toplam 6 olgu, %18.7) mikroalbuminüri saptandı. Ortalama HbA1c değeri grup 1'de %12, grup 2'de %12.4 olmak üzere benzer düzeyde bulundu. Grup 1 ve grup 2'de Apo A1, grup 1'de trigliserid düzeyleri kontrol grubuna göre yüksek bulundu (p0.05).

Anahtar Kelimeler:

Albüminler, Apolipoproteinler, Çocuk, Lipoproteinler, Trigliseridler, Diabetes mellitus, insülin bağımlı

Serum lipoprotein and apolipoprotein levels in children with insulin dependent diabetes mellitus

Serum lipid and lipoproteins were evaluated in 32 children with insulin dependent diabetes mellitus (IDMM) followed 1-9 years. Patients divided into two groups. Group 1 included 22 patients followed 1-5 years and group 2 included 10 patients followed above 5 years. Thirty healthy children served as controls. Microalbuminuria was detected in six cases with IDDM (18.7%, either three patients in both groups). The mean HbA1c levels were similar in patients in both groups (12% in grup 1 and 12.4% in grup 2). Apo A1 was higher in group 1 and 2 than control group (p<0.01). Higher trigliserid value was found in group 1 compared with controls (p<0.01). There was no significant correlation between serum lipid values and HbA1c levels in patients (p>0.05).

Keywords:

Albumins, Apolipoproteins, Child, Lipoproteins, Triglycerides, Diabetes Mellitus, Insulin-Dependent,

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