Canan GÜRSOY, Ezgi DÖNMEZ, Semra GÜMÜŞ DEMİRBİLEK

Plazmaferez Sırasında Fatal Seyreden TRALI

Transfüzyon ilişkili akut akciğer hasarı (TRALI); transfüzyon sırasında veya 6 saat içinde ortaya çıkan, akut hipoksemi ve non-kardiyojenik ödem ile karakterize tablodur. Non-kardiyojenik pulmoner ödeme bağlı hipoksi, dispne, siyanoz, ateş ve taşikardi görülür. Transfüzyona bağlı ölümlerin hemolizden sonraki en sık sebebidir. Transfüzyon ilişkili akut akciğer hasarına en sık plazma ve trombosit replasmanının neden olduğu bilinmektedir. Transfüzyon sayısı arttıkça TRALI riski artmaktadır. Kan ve kan ürünlerinin bilinen kullanım endikasyonlarının yanı sıra plazmaferez gibi işlemlerde de kullanımı giderek yaygınlaşmıştır. Bu nedenle klinisyenlerin transfüzyon ilişkili komplikasyonlar ile karşılaşma ihtimali artmaktadır. Biz bu yazıda replasman mayi olarak taze donmuş plazmanın kullanıldığı plazmaferez sırasında gelişen akut akciğer hasarını literatür eşliğinde sunmayı amaçladık.

Anahtar Kelimeler:

Plazmaferez, Taze Donmuş Plazma, Transfüzyon İlişkili Akut Akciğer Hasarı, Transfüzyon Reaksiyonu

The Fatal TRALI During the Plasmapheresis A Fatal TRALI

Transfusion related acute lung injury (TRALI) is characterized by acute hypoxemia and non-cardiac edema which occurs during the transfusion or within the first 6 hours. Hypoxia, dyspnea, cyanosis, fever and tachycardia are caused by non-cardiac pulmonary edema. Transfusion-related deaths are the most common cause after hemolysis It is known that TRALI is mostly seen with plasma and platelet replacements. The risk of development of TRALI rises with the increasing number of transfusions. The use of blood and blood components for plasmapheresis and similar processes alongside the routine indications has become increasingly widespread. Therefore clinicians are more likely to meet the complications related with transfusion. In this study, we purposed to present an acute lung injury case caused by fresh frozen plasma during plasmapheresis in the context of the literature.

Keywords:

Fresh Frozen Plasma, Plasmapheresis, Transfusion Reaction, Transfusion Related Acute Lung Injury,

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