Farklı Tiroid Patolojilerinin Ayrımında Nötrofil Lenfosit Oranının Prediktif Rolü

Nörtofil lenfosit oranı (NLO) ve platelet lenfosit oranı (PLO) sistemik enflamatuar yanıtın basit bir göstergesidir ve bazı hastalıklarda prognostik olduğu gösterilmiştir. Bu çalışma NLO ve PLO ile tiroid kanseri ve tiroidin multinodüler guatr ve tiroidit gibi diğer benign hastalıkları arasındaki ilişkiyi ortaya koymak amacı ile gerçekleştirildi. Hastanemiz genel cerrahi kliniğinde 2015-2017 yılları arasında tiroidektomi ameliyatı olan 331 hasta değerlendirildi. Hastaların laboratuar bulguları, demografik özellikleri ve patoloji raporları geriye dönük olarak incelendi. Patoloji raporlarına göre hastalar 4 gruba ayrıldı. 331 hastanın 241’ine MNG (MNG Grup), 17’sine tiroidit (T Grup), 49’una tiroid karsinomu (TK Grup), 24’üne ise tiroidit ile birlikte tiroid karsinomu (T-TK Grup) teşhisi konuldu. Hastalar ayrıca malignite varlığına göre göre benign (n=258) ve malign (n=73) olarak 2 gruba ayrıldı. Grupların NLO ve PLO değerleri karşılaştırıldı. Hastaların 292’si kadın (%88.2), 39’u erkek (%11.8) olup ortalama yaş 50.52±12.08 idi. Dört grup arasında NLO ve PLO değeri açısından istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Bununla birlikte malignite varlığına göre malign grubun NLO değeri, benign grubun NLO değerine göre istatistiksel olarak anlamlı düzeyde yüksek saptandı (p=0.039; p<0.05). Malignite varlığına göre grupların PLO ölçümleri arasında istatistiksel olarak anlamlı farklılık saptanmadı (p>0.05). Bizim çalışmamızda farklı tiroid patolojileri ile NLO ve PLO arasında ilişki saptanmadı. Konu ile ilgili prospektif, randomize geniş serili çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler:

Guatr, Tiroid Karsinomu, Nötrofil/Lenfosit Oranı

Predictive Role of Neutrophil to Lymphocyte Ratio in Differentiation of Different Thyroid Pathologies

The neutrophil/lymphocyte ratio (NLR) and platelete/ lymphocyte ratio (PLR) is a simple marker of systemic inflamatory response. The aim of this study was to examine the relationship of NLR and PLR with thyroid cancer and different benign thyroidal pathologies such as multi nodular goiter and thyroiditis. 331 patients who underwent thyroidectomy in general surgery department of our hospital between 2015 and 2017 were evaluated. Laboratory findings, demographic characteristics and pathology reports of patients were retrospectively reviewed. Patients were devided into four groups according to pathological reports. 241 of 331 patients were diagnosed with MNG (MNG Group), 17 were thyroiditis (T group), 49 were thyroid carcinomas (TK Group) and 24 were thyroid carcinoma with thyroiditis (T-TK Group). Patients were also devided into two groups according to precence of malignancy as benign (n=258) and malign (n=73). NLR and PLR values of groups were compared. 292 (88.2%) of paitents were female and 39 (11.8%) were male with a mean age was 50.52±12.08 years. There was no statistically significant difference between four groups in terms of NLR and PLR values (p>0.05). However, according to presence of malignancy, NLR values of malignant group was found to be statistically higher than the NLR values of benign group (p=0.039; p<0.05). There were no difference between two groups according to PLR values (p>0.05). In our study, there was no relationship between different thyroid pathologies and NLR and PLR. There is a need for prospective, randomized, large series of studies on the subject.

Keywords:

Goiter, Neutrophil/Lymphocyte Ratio, Thyroid Carcinomas,

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