Eozinofilik Püstüler Dermatoz: 50 Yılın Ardından

Eozinofilik püstüler dermatoz (EPD), kıl folliküllerinin eozinofilik infiltrasyonu ile karakterize non-infeksiyöz bir dermatozdur. İlk kez 1965 yılında Ise ve Ofuji tarafından kollar ve yüzde püstüller izlenen kadın olguda histopatolojik incelemede foliküllerin eozinofilik infiltrasyonu ve periferik kanda lökositoz saptanması üzerine tanımlanmıştır ve bu form klasik EPD olarak bilinmektedir. Yıllar içinde klasik EPD dışında immünsupresyonla ilişkili EPD (çoğunlukla HIV ile ilişkili) ve infantil EPD olmak üzere üç formu tanımlanmıştır ve bazı araştırmacılar birbirinden klinik olarak büyük farklar gösteren bu üç formun farklı birer hastalık olarak ele alınmasını önermektedir. Tanımlanmasının üzerinden elli yıldan fazla süre geçen bu nadir antiteyi gözden geçirmekteyiz.

Anahtar Kelimeler:

eozinofilik püstüler dermatoz, follikülit, eozinofili

Eosinophilic Pustular Dermatosis: After 50 Years

Eosinophilic pustular dermatosis (EPD) is a non-infectious dermatosis characterized by eosinophilic infiltration of hair follicles. It was first described by Ise and Ofuji in 1965 in a female case with pustules on the arms and face, and eosinophilic infiltration of the follicles and leukocytosis in the peripheral blood were detected in the histopathological examination, and this form is known as classical EPD. Over the years, apart from classical EPD, three forms of immunosuppression-related EPD (mostly HIV-related) and infantile EPD have been defined, and some researchers suggest that these three forms, which differ clinically from each other, should be considered as different diseases. We review this rare entity, more than fifty years after its description.

Keywords:

eosinophilic pustular dermatosis, eosinophilia, folliculitis,

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1. Ise S, Ofuji S. Subcorneal pustular dermatosis. A follicular variant? Arch Dermatol. 1965;92:169-71.
2. Soeprono FF, Schinella RA. Eosinophilic pustular folliculitis in patients with acquired immunodeficiency syndrome. Report of three cases. J Am Acad Dermatol. 1986;14:1020-2.
3. Lucky AW, Esterly NB, Heskel N. Eosinophilic pustular folliculitis in infancy. Pediatr Dermatol. 1984;1:2020-6.
4. Rosenthal D, LeBoit PE, Klumpp L, et al. Human immunodeficiency virus-associated eosinophilic folliculitis. A unique dermatosis associated with advanced human immunodeficiency virus infection. Arch Dermatol. 1991;127:206-9.
5. Hayes BB, Hille RC, Goldberg LJ. Eosinophilic folliculitis in 2 HIVpositive women. Arch Dermatol. 2004;140:463-5.
6. Tang MB, Tan E, Chua SH. Eosinophilic pustular folliculitis (Ofuji’s disease) in Singapore: a review of 23 adult cases. Australas J Dermatol. 2003;44:44-7.
7. Ofuji S. Eosinophilic pustular folliculitis. Dermatologica. 1987;174:53-6.
8. Takematsu H, Tagami H. Eosinophilic pustular folliculitis. Studies on possible chemotactic factors involved in the formation of pustules. Br J Dermatol. 986;114:209-15.
9. Ellis E, Scheinfeld N. Eosinophilic pustular folliculitis: a comprehensive review of treatment options. Am J Clin Dermatol. 2004;5:189-97.
10. Kostler E, Gossrau G, Kuster P. Sterile eosinophilic pustulosis (Ofuji). A rare entity in Europe. Hautarzt 1995;46:643-6.
11. Fearfield LA, Rowe A, Francis N, et al. Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. Br J Dermatol. 1999;141:3-11.
12. Rajendran PM, Dolev JC, Heaphy MR Jr, et al. Eosinophilic folliculitis: before and after the introduction of antiretroviral therapy. Arch Dermatol. 2005;141:1227-31.
13. Giard F, Marcoux D, McCuaig C. Eosinophilic pustular folliculitis (Ofuji disease) in childhood: a review of four cases. Pediatr Dermatol. 1991;8:189-93.
14. Ziemer M, Boer A. Eosinophilic pustular folliculitis in infancy: not a distinctive inflammatory disease of the skin. Am J Dermatopathol. 2005;27:443-55.
15. McCalmont TH, Altemus D, Maurer T, et al. Eosinophilic folliculitis. The histologic spectrum. Am J Dermatopathol. 1995;17:439-46.
16. Piantanida EW, Turiansky GW, Kenner JR, et al. Immunosuppression-associated eosinophilic folliculitis: diagnosis by transverse histologic sections. J Am Acad Dermatol. 1998;38:124-6.
17. Rupnik H, Podrumac B, Zgavec B, et al. Follicular mucinosis in a teenage girl. Acta Dermatovenerol Alp Panonica Adriat. 2005;14:111-4.
18. Haupt HM, Stern JB, Weber CB. Eosinophilic pustular folliculitis: fungal folliculitis? J Am Acad Dermatol. 1990;23:1012-4.
19. Maejima H, Mukai H, Hikaru E. Eosinophilic pustular folliculitis induced by allopurinol and timepidium bromide. Acta Derm Venereol. 2002;82:316-7.
20. Takematsu H, Tagami H. Eosinophilic pustular folliculitis. Studies on possible chemotactic factors involved in the formation of pustules. Br J Dermatol. 1986;114:209-15.
21. Amerio P, Verdolini R, Proietto G, et al. Role of Th2 cytokines, RANTES and eotaxin in AIDSassociated eosinophilic folliculitis. Acta Derm Venereol. 2001;81:92-5.
22. Kimoto M, Ishihara S, Konohana A. Eosinophilic pustular folliculitis with polycythemia vera. Dermatology. 2005;210:239-40.
23. Lee MW, Lee DP, Choi JH, et al. Failure to detect clonality in eosinophilic pustular folliculitis with follicular mucinosis. Acta Derm Venereol. 2004;84:305-7.
24. Nervi SJ, Schwartz RA, Dmochowski M. Eosinophilic pustular folliculitis: a 40 year retrospect. J Am Acad Dermatol. 2006;55(2):285-9.
25. Mizukawa Y, Shiokara T. Eosinophilic pustular folliculitis induced after prolonged treatment with systemic corticosteroids in a patient with pustulosis palmoplantaris. Acta Derm Venereol 1998;78:221-2.