Ulaş DEĞİRMENCİ, Metin YILDIRIM, Serap YALIN

Ateroskleroz patofizyolojisinde Kruppel Benzeri Faktör 14’ün rolü

Kardiyovasküler hastalıklar (KVH) dünya genelinde ölümlerin üçte birinden sorumludur. Bu hastalıklarda görülen ortak patolojik durum aterosklerozdur. Ateroskleroz, erken safhalarında endotelyal hücre aktivasyonu/disfonksiyonunun görülmesi sebebiyle inflamatuar bir hastalık olarak nitelendirilmektedir. Ateroskleroz patolojisinin kötü kolesterol olarak bilinen düşük yoğunluklu lipoprotein kolesterolün (LDL-C) kandaki düzeyinin artması ve iyi kolesterol olarak bilinen yüksek yoğunluklu lipoprotein kolesterolün (HDL-C) düzeyinin ise azalması gibi lipit metabolizma bozuklukları (dislipidemi) ile karakterize olduğu birçok çalışmada gösterilmiştir. Çeşitli epidemiyolojik çalışmalarda Tip II diyabetli (T2D) hastaların ateroskleroz ve Koroner Arter Hastalığı (KAH) komplikasyonları geliştirme riskinin daha yüksek olduğu belirtilmiştir. Çinko parmak motif transkripsiyon faktörü ailesinin üyesi olan Kruppel benzeri faktörler (KLF) normal biyolojik süreçlerde ve patolojik durumlarda gerekli olan genlerin aktivitesini düzenlemektedirler. Yapılan çalışmalarda KLF14’ün aterosklerotik KVH’da önemli rolü olduğu gösterilmiştir. Bu derlemede KLF14’ün ateroskleroz patofizyolojisindeki rolüne değinilecektir.

Anahtar Kelimeler:

Ateroskleroz, Kruppel benzeri faktör 14, Dislipidemi, Obezite, Diyabet

The role of Kruppel-Like Factor 14 in the pathophysiology of atherosclerosis

Cardiovascular diseases (CVD) are responsible for one third of deaths worldwide. The common pathological condition seen in these diseases is atherosclerosis. Atherosclerosis is characterized as an inflammatory disease due to endothelial cell activation / dysfunction in its early stages.It has been shown in many studies that atherosclerosis pathology is characterized by lipid metabolism disorders (dyslipidemia), such as increased levels of low-density lipoprotein cholesterol (LDL-C) known as bad cholesterol and decreased levels of high-density lipoprotein cholesterol (HDL-C) known as good cholesterol. Various epidemiological studies have reported that patients with Type II diabetes (T2D) have a higher risk of developing complications of atherosclerosis and Coronary Artery Disease (CAD). Kruppel-like factors (KLF), a member of the zinc-finger motif transcription factor family, regulate the activity of genes required in normal biological processes and pathological conditions. KLF 14 has been shown to play an important role in atherosclerotic CVDs. In this review, the role of KLF14 in the pathophysiology of atherosclerosis will be discussed.

Keywords:

Atherosclerosis, Kruppel-like Factor 14, dyslipidemia, obesity,

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