Comparing the role of diffusion-weighted imaging magnetic resonance (DWI-MR) in leiomyomas (LM), which can be in pathologically different variants such as cellular, mitotic active, atypical myoma (bizarre nuclei) and STUMP (smooth muscle tumors of uncertain malignant potential), to clinical findings for determining the malignant potential of myoma. Fifty patients who were diagnosed with myoma uteri between March 2013 and April 2017 and evaluated with DWI-MR in the preoperative period were included in the study. Clinical parameters and DWI-MR evaluations of LMs and atypical LMs were compared. While there was no difference in the clinical parameters between LM and atypical LM, there was a significant difference between abnormalities detected by DWI-MR (diffusion restriction, hypervascularity) (p = 0.012). DWI-MR may be a guide for preoperative leiomyoma evaluation, especially in patients who are planned to sustain fertility.
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1. Wamsteker K, Emanuel MH, de Kruif JH. "Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension." Obstet Gynecol. 1993; 82:736.
2. Arleo EK, Schwartz PE, Hui P, et al. AJR Review of leiomyoma variants. Am J Roentgenol. 2015;205:912-21.
3. Zaki Sleiman ,Sara Hussein, Amani Mohsen, et al. Antonio Biondi Laparoscopic management of uncommon benign uterine tumors:a systematic review. Updates Surgery. 2019;71:637–43.
4. Chen I, Firth B, Hopkins L, et al. Clinical characteristics differentiating uterine sarcoma and fibroids. JSLS. 2018;22:e2017.00066.
5. Trop e CG, Abeler VM, Kristensen GB. Diagnosis and treatment of sarcoma of the uterus. Acta Oncol. 2012 ,51:694–705.
6. Van den Bosch T, Coosemans A, Morina M, et al. Screening for uterine tumours. Best Pract Res Clin Obstet Gynaecol. 2012;26:257–66.
7. Wu T, Yen T, Lai C. Clinical presentation and diagnosis of uterine sarcoma, including imaging. Best Pract Res Clin Obstet Gynaecol. 2011;25:681–9.
8. V Foti, C Tilocca, A Sigona, et al. Benign neoplasms of the uterus: MR imaging of leiomyomas with radiologic-pathologic correlation P - WCRJ. 2015.
9. Tamai K, Koyama T, Saga T, et al. The utility of diffusionweighted MR imaging for differentiating uterine sarcomas from benign leiomyomas. Eur Radiol. 2008;18:723–30.
10. Lin G, Yang LY, Huang YT, et al. Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma/smooth muscle tumor with uncertain malignant potential and benign leiomyoma. J Magn Reson Imaging. 2016;43:333-42.
11. Valdes-Devesa V, Jimenez MDM, Sanz-Rosa D, et al. Preoperative diagnosis of atypical pelvic leiomyoma and sarcoma: the potential role of diffusion-weighted imaging. J Obstet Gynaecol. 2019;39:98-104.
12. Li HM, Liu J, Qiang JW, et al. Diffusion-weighted imaging for differentiating uterine leiomyosarcoma from degenerated leiomyoma. J Comput Assist Tomogr. 2017;41:599–606.
13. Munro MG, Critchley HO, Broder MS, et al. FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113:3-13.
14. Y Lakhman , H Veeraraghavan, J Chaim et al. Differentiation of uterine leiomyosarcoma from atypical leiomyoma: diagnostic accuracy of qualitative mr imaging features and feasibility of texture analysis. Eur Radiol. 2017;27:2903–15.
15. FA Taran, AL Weaver, BS Gostout, et al. Understanding cellular leiomyomas: a case-control study. Am J Obstet Gynecol. 2010;203:109.
16. Ly A, Mills AM, McKenney JK, et al. Atypical leiomyomas of the uterus: a clinicopathologic study of 51 cases. Am J Surg Pathol. 2013;37:643-9.
17. JH Kim, YJ Choi, DC Kim, et al. Leiomyosarcoma arising in a patient with prior mitotic