Asude KARA POLAT, Sümeyre Seda ERTEKİN, Müge GÖRE KARAALİ, Ayşe Esra KOKU AKSU, Mehmet Salih GÜREL

Evaluation of quality of life in female patients with melasma

Melasma is an acquired pigmentation disease occurs on the face and neck, sun-exposed areas. It significantly affects the quality of life of the patients. The objective of this study was to evaluate the quality of life in patients with melasma. A prospective cross-sectional study was conducted on 49 female patients diagnosed with melasma between November 2016 and March 2017 in a tertiary referral hospital dermatology outpatient clinic. The patients were evaluated according to age, marital status, education level, Fitzpatrick skin type, puberty age, the duration of disease, family history, medical comorbidities. Disease severity were measured with the melasma area and severity index (MASI). The patients were evaluated according to quality of life scales: Turkish version of the melasma quality-of-life questionnaire (MelasQoL-TR), Dermatology Life Quality Index (DLQI), Turkish version of Skindex 16. The correlation between the severity of the disease and the qualities of life of the patients were evaluated. Fourty-nine female patients with the mean age of 36.8 ± 7.8 enrolled in the study. Fitzpatrick skin type III (49.6%) and IV (49.0%) were the most common skin phototypes. The mean disease duration was 56.7 ± 49.0 months. The mean MASI score was 16.3 ± 8.7. The mean MeLaSQoL-TR score, DLQI score and Skindex 16 score were 34.4 ± 13.0, 15.1 ± 7.6, 34,7 ± 16,9 respectively. Significant positive correlation was found between MASI score and MelasQoL-TR, DLQI and Skindex 16 scores (p ˂ 0.05). When the scores of emotion and function of Skindex 16 were evaluated separately, there was a significant positive correlation between MASI score and these scores (p ˂ 0.05). However no significant correlation was observed between MASI score and Skindex 16 symptom score (p ˃ 0.05). There was a significant correlation between these three different life quality scales. Age and education level were not significantly related with quality of life scales in our study. In this study, all scale scores were high in patients with melasma, and were correlated with severity of the disease. Melasma has a significant emotional and functional impact on quality of life in female patients.

PDF

___

1. KrupaShankar DS, Somani VK, Kohli M, et al. A cross-sectional, multicentric clinico-epidemiological study of melasma in India. Dermatol Ther. (Heidelb) 2014;4:71-81.

2. Harumi O, Goh CL. The Effect of melasma on the quality of life in a sample of women living in singapore. J Clin Aesthet Dermatol. 2016;9:21-4.

3. Balkrishnan R, McMichael AJ, Camacho FT et al. Development and validation of health-related quality of life instrument for women with melasma. Br J Dermatol. 2003;149: 572–7.

4. Dogramaci AC, Havlucu DY, Inandi T, et al. Validation of a melasma quality of life questionnaire for the Turkish language: the MelasQoL-TRstudy. J Dermatolog Treat. 2009;20:95-9.

5. Kimbrough-Green CK, Griffiths CE, Finkel LJ, et al. Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle controlled clinical trial. Arch Dermatol. 1994;130:727–33.

6. Gurel MS, Yanik M, Simsek Z, et al. Quality of life instrument for Turkish people with skin diseases. Int J Dermatol. 2005;44:933-8.

7. Koku Aksu AE, Saraçoglu ZN, Sabuncu I, et al. Validity and reliability of the Turkish version of the Skindex-16. Turkderm. 2016;50:109-13.

8. Chang MW. Disorders of Hyperpigmentation. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds, Dermatology. 3rd edition. Mosby Elsevier, St. Louis, 2012;1052-4.

9. Handel AC, Miot LD, Miot HA. Melasma: a clinical and epidemiological review. An Bras Dermatol. 2014;89:771-82.

10. Seçkin HY, Kalkan G, Baş Y, et al. Oxidative stress status in patients with melasma. Cutan Ocul Toxicol. 2014;33:212-7.

11. Hexsel D, Lacerda DA, Cavalcante AS, et al. Epidemiology of melasma in Brazilian patients: a multicenter study. Int J Dermatol. 2014 ;53:440-4.

12. Ortonne JP, Arellano I, Berneburg M, et al. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma. J Eur Acad Dermatol Venereol. 2009;23:1254-62.

13. Rostami Mogaddam M, Iranparvar Alamdari M, Maleki N, et al. Evaluation of autoimmune thyroid disease in melasma. J Cosmet Dermatol. 2015;14:167- 71.

14. Ali R, Aman S, Nadeem M, Kazmi AH. Quality of life in patients of melasma. J Pakistan Association Dermatols. 2013;23:143-8.

15. Freitag FM, Cestari TF, Leopoldo LR, et al. Effect of melasma on quality of life in a sample of women living in southern Brazil. J Eur Acad Dermatol Venereol. 2008;22:655-62.

16. Ikino JK, Nunes DH, Silva VP, et al. Melasma and assessment of the quality of life in Brazilian women. An Bras Dermatol. 2015;90:196-200.

17. Chren MM, Lasek RJ, Sahay AP, et al. Measurement properties of Skindex-16: a brief quality-of-life measure for patients with skin diseases. J Cutan Med Surg. 2001;5:105-10.