Sema ARISOY, Tansel ÇOMOĞLU

Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles

ISSN: 2147-0634
Yayın Aralığı: 4
Başlangıç: 2012
Yayıncı: Effect Publishing Agency ( EPA )

Drug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fundamental quality parameter of all type of drugs. Kinetic models are developed to determine drug release from delivery systems which the released drug amount (Q) is plotted versus time; t or as a function of time Q=f (t). Kinetic models facilitate the understanding of release pattern in enabling to design an effective formulation. In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. Higuchi, zero order, first order, Hixon Crowell and Korsmeyer-Peppas models were investigated. Hixson Crowell model was found to be the best fitted kinetic model in L-Dopa loaded nanoparticles (r2 =0.9828).

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1. Anderson N, Bauer M, Boussac N, et al. An evaluation of fit factors and dissolution efficiency for the comparison of in vitro dissolution profiles. J Pharm Biomed Anal. 1998;17:811-22.

2. Yuksel N, Kanık AE, Baykara T. Comparison of in vitro dissolution profiles by ANOVA-based, model-dependent and-independent methods. Int J Pharm. 2000;209:57-67.

3. Sathe MP, Tsong Y, Shah VP. In vitro dissolution profile comparison: stastics and snalysis, model dependent approach. Pharm Res. 1996;13:803-1799.

4. Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;2001:123-33

5. Park TG. Degradation of poly (lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials. 1995;16:1123-30.