ABDURRAHMAN ŞAHİN, Yılmaz BİLGİÇ, Mustafa CENGİZ, Hasan Baki ALTINSOY

Isolated CA 19-9 elevation as preceding finding of colorectal carcinoma

Rectal bleeding, change in bowel habits, abdominal pain are cardinal symptoms of colorectal carcinoma. Otherwise, weight loss, fatigue and weakness do not suggest colorectal carcinoma. Carbohydrate antigen (CA) 19-9 level is higher in several malignancies, especially gastrointestinal malignancies, and some benign conditions. Herein, we present a patient who is referred to our clinic with the complaint of fatigue and significant CA 19-9 elevation, diagnosed as metastatic colorectal carcinoma. Presenting case highlights that CA 19-9 elevation might be the only finding of colorectal carcinoma in even patients with nonspecific complaints

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1. Goonetilleke KS, Siriwardena AK. Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer. Eur J Surg Oncol. 2007;33(3):266-70.

2. Stiksma J, Grootendorst DC, van der Linden PW. CA 19-9 as a marker in addition to CEA to monitor colorectal cancer. Clin Colorectal Cancer. 2014;13(4):239-44.

3. Ballehaninna UK, Chamberlain RS. Serum CA 19-9 as a Biomarker for Pancreatic Cancer-A Comprehensive Review. Indian J Surg Oncol. 2011;2(2):88-100.

4. Marrelli D, Caruso S, Pedrazzani C, Neri A, Fernandes E, Marini M, Pinto E, Roviello F. CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions. Am J Surg. 2009;198(3):333-9.

5. Bertino G, Ardiri AM, Calvagno GS, Malaguarnera G, Interlandi D, Vacante M, Bertino N, Lucca F, Madeddu R, Motta M. Carbohydrate 19.9 antigen serum levels in liver disease. Biomed Res Int. 2013;2013:531640.

6. Shin JY, Yoo SJ, Park BM, Jung SS, Kim JO, Lee JE. Extremely increased serum carbohydrate antigen 19-9 levels caused by new or resistant infections to previous antibiotics in chronic lung diseases. Tuberc Respir Dis (Seoul). 2013;75(3):125-7.

7. Cho HY, Kim K, Jeon YT, Kim YB, No JH. CA19-9 elevation in ovarian mature cystic teratoma: discrimination from ovarian cancer - CA19-9 level in teratoma. Med Sci Monit. 2013;19:230-5.

8. Santini D, Altomare A, Vincenzi B, Perrone G, Bianchi A, Rabitti C, Montesarchio V, Esposito V, Baldi A, Tonini G. An increase of CA 19.9 as the first clinical sign of ileocecal valve metastasis from breast cancer. In Vivo. 2006;20(1):165-8.

9. Kannagi R. Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progression. Chang Gung Med J. 2007;30(3):189-209.

10. Reiter W, Stieber P, Reuter C, Nagel D, Lau-Werner U, Lamerz R. Multivariate analysis of the prognostic value of CEA and CA 19-9 serum levels in colorectal cancer. Anticancer Res. 2000;20(6D):5195-8.

11. Dong H, Tang J, Li LH, Ge J, Chen X, Ding J, Men HT, Luo WX, Du Y, Li C, Zhao F, Chen Y, Cheng K, Liu JY. Serum carbohydrate antigen 19-9 as an indicator of liver metastasis in colorectal carcinoma cases. Asian Pac J Cancer Prev. 2013;14(2):909-13.