Nezaket KADİOGLU, SİBEL ÖZLER, Eda GULMEZ, Basak GUMUS, Ebru Aslan PATLAKOGLU

Comparison of Liquid Based Cytology Results with Conventional Cytology Results in Screening Cervical Cancer

Our objective is to compare and evaluate the liquid based cytology (LBC) results with the conventional cytology (CC) results for cervical cancer. Cross sectional study. The results of 1531 women, applied to our outpatient clinic, for cervical cancer screening between the years 2012- 2015, were evaluated. We have applied liquid based cytology on 958 (62.6%) of the patients, and conventional cytology on 573 (37.4%) of the patients. Unsatisfactory smear results for examination were found to be significantly lower in LBC compared to CC (20.3% vs. 0.4%, p<0.001). Atypical squamous cells of undetermined significance (ASC-US) and atypical squamous cells, cannot exclude high-grade lesion (ASC-H) detection rates were significantly higher in LBC compared to CC (3% vs. 1.7%, p<0.001). Between the ages 18 to 35, ASC-US and ASC-H rates were also significantly higher in LBC, when compared to CC (5.2% vs. 1%, p<0.001). Even though ASC-US and ASC-H rates in patients aged 18 to 35 were higher than other groups, no significant difference was observed. Age was a significant risk factor in cervical epithelial anomalies (p<0.001). LBC was found to be a better method than CC for obtaining accurate results on cervical epithelial anomalies, in all ages

PDF

___

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.

Munoz N, Bosch FX, Castellsagué X, Díaz M, de Sanjose S, Hammouda D, Shah KV, Meijer CJ. Against which human papillomavirus types shall we vaccinate and screen? The international perspective. Int J Cancer. 2004;111(2):278-85.

Smith RA, Cokkinides V, Brawley OW. Cancer screening in the United States, 2009: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. 2009;59(1):27-41.

Gustafsson L, Ponten J, Bergstrom R, Adami HO. International incidence rates of invasive cervical cancer before cytological screening. Int J Cancer. 1997;71(2):159-65.

Bernstein SJ, Sanchez-Ramos L, Ndubisi B. Liquid-based cervical cytologic smear study and conventional Papanicolaou smears: a metaanalysis of prospective studies comparing cytologic diagnosis and sample adequacy. Am J Obstet Gynecol. 2001;185(2):308-17.

Abulafia O, Pezzullo JC, Sherer DM. Performance of ThinPrep liquid-based cervical cytology in comparison with conventionally prepared Papanicolaou smears: a quantitative survey. Gynecol Oncol. 2003;90(1):137-44.

Yang BH, Bray FI, Parkin DM, Sellors JW, Zhang ZF. Cervical cancer as a priority for prevention in different world regions: an evaluation using years of life lost. Int J Cancer. 2004;109(3):418-24.

Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T Jr, Young N; The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002; 287(16): 2114-9.

Atilgan R, Celik A, Boztosun A, Ilter E, Yalta T, Ozercan R. Evaluation of cervical cytological abnormalities in Turkish population. Indian J Pathol Microbiol. 2002;55(1):52-5.

Klinkhamer PJ, Meerding WJ, Rosier PF, Hanselaar AG. Liquid-based cervical cytology. Cancer. 2003;99(5):263-71.

ASCUS-LSIL Traige Study (ALTS) Group. A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol. 2003;188(6):1393-400.

Berman ML. Advances in cervical cancer management from North American cooperative group clinical trials. Yonsei Med J. 2002;43(6):729-36.

Diaz-Rosario LA, Kabawat SE. Performance of a fluid-based, thin-layer papanicolaou smear method in the clinical setting of an independent laboratory and an outpatient screening population in New England. Arch Pathol Lab Med. 1999;123(9):817-21.

Beerman H, Van Dorst EB, Kuenen-Boumeester V, Hogendoorn PC. Superior performance of liquid-based versus conventional cytology in a population-based cervical cancer screening program. Gynecol Oncol. 2009;112(3):572-6.

Williams AR. Liquid-based cytology and conventional smears compared over two 12- month periods. Cytopathology. 2006;17(2):82-5.

Kashyap V, Bhambhani S. Incidence and cytomorphological peculiarities of lower genital tract infections in vault (post hysterectomy) smears versus pap smears from non-hysterectomy subjects: a retrospective study. J Obstet Gynaecol India. 2001;61(5):558-61.

Juneja A, Sehgal A, Mitra AB, Pandey A. A survey on risk factors associated with cervical cancer. Indian J Cancer. 2003;40(1):15-22.

Reiter PL, Katz ML, Ferketich AK, Ruffin MTt, Paskett ED. Measuring cervical cancer risk: development and validation of the CARE Risky Sexual Behavior Index. Cancer Causes Control. 2009;20(10):1865-71.