The incidence of choroid plexus cyst (CPC), in trisomy 18 45-50 %, in trisomy 21 1-2%. For this reason, the effect of bilaterality, size, and multiplicity of CPC on the aneuploidy risk is controversial. İn this case report we discussed the effect of multiplicity of CPC on the aneuploidy risk. Generally accepted opinion is positive first and second trimester screening test or detection of another malformation with sonography is more important than laterality or multiplicity of CPC for karyotype analyzing. Prenatal karyotyping is needed when maternal serum screening markers are abnormal or another markers are found on sonogram. Thirty-year-old (gravida 3, parity 2) referred at 19 weeks gestation due to 6.4 mm, 6 mm, 4 mm unilateral, multiple CPC formation. In second trimester sonography, there was no another abnormal ultrasound abnormality detected. Maternal serum second trimester and quadruple test results were normal. Amniocentesis was not applied to the patient. At the term, the healthy baby was delivered
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