Yasemin TURAN, Serpil BAL, Serpil KARAYAĞIZ, Alev GÜRGAN

ANKİLOZAN SPONDİLİT HASTALARINDA SERUM IL-8 DÜZEYİ VE HASTALIK AKTİVİTESİ İLE İLİŞKİSİ

Amaç:Ankilozan spondilit (AS) başlıca sakroiliak eklem ve lomber omurga olmak üzere aksiyel iskelettutulumu ile giden kronik inflamatuar bir hastalıktır. Hastalığın patogenezinden sitokinlerin sorumlu olabileceğidüşünülmektedir. Bu çalışmanın amaçlarını AS'li hastalarda serum IL-8 düzeylerinin belirlenmesi ve IL-8düzeyleri ile hastalık aktivitesi arasındaki ilişkinin saptanması oluşturmaktadır.Gereç ve Yöntem:Modifiye New York kriterlerine göre AS tanısı almış 28 hasta çalışmaya dahil edildi.Hastaların klinik değerlendirilmelerinde BASDAI, BASFİ, BASMİ ve Maastricht Ankylosing SpondylitisEnthesis Score (MASES) indeksleri kullanıldı. ELISAyöntemi ile serum IL-8 düzeyleri ölçüldü.Bulgular: Hastaların ortalama yaş ve hastalık süreleri sırasıyla 35,4±10,8 yıl ve 75±97,1 ay olarak saptandı.Serum IL-8 düzeyleri ortalama 67,3±22,9 pg/mL olarak ölçüldü. Serum IL-8 düzeyinin diğer klinik ve laboratuarparametreler ile karşılaştırılmasında, sadece C-reaktif protein düzeyi (P=0,048) ve BASDAI (P=0,005) ileanlamlı ilişki gösterdiği gözlendi.Sonuç: BASDAI ve CRP AS'li hastaların klinik aktivitelerini değerlendirmede kullanılan iki önemliparametredir. Bu çalışmada saptanan serum IL-8 ile BASDAI ve CRP arasındaki ilişki serum IL-8 düzeylerininhastalık aktivitesinin takibinde kullanılabilecek objektif bir belirteç olduğunu gösterebilir

Anahtar Kelimeler:

Ankilozan spondilit, hastalık aktivitesi, interlökin-8

Correlation Between Serum IL-8 Levels and Disease Activity in Patients With Ankylosing Spondylitis

Objective: Ankylosing Spondylitis (AS) is a chronic inflammatory disorder of the axial skeleton, affecting mainly the sacroiliac joints and the lumbar spine. Cytokines are believed to be responsible for the pathogenesis of the disease. The aims of this study were to determine serum interleukin-8 (IL-8) levels inAS patients and also to determine the relationship between these levels and disease activity. Materials and Methods: Twenty-eight patients with a diagnosis of AS according to the modified New York criteria were included in this study. BASDAI, BASFI, BASMI and Maastricht Ankylosing Spondylitis Enthesis Score (MASES) indexes were used for clinical evaluation of the patients. Serum IL-8 levels were measured by ELISA. Results: The mean age and disease duration of the patients were 35.4(10.8) years and 75(97.1) months respectively. The mean serum IL-8 level was 67.3(22.9) pg/mL. Among the evaluated clinical and laboratuary parameters a significant correlation was observed only between serum IL-8 levels and CRP (p=0,048) and also BASDAI(P=0,005). Conclusion: BASDAI and CRPare two important clinical parameters which are used in the evaluation of disease activity inAS patients. Finding a significant relationship between serum IL-8 level and these two parameters may indicate that serum IL-8 level could be used as an objective marker to monitor the disease activity inASpatients.

Keywords:

Ankylosing spondylitis, disease activity, interleukin-8,

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