İbrahim METEOĞLU, Hicran TURHAN, Hakan ÇEVİKEL

AMİLOİD GUATR: OLGU SUNUMU

Amiloidoz vücuttaki birçok organ ve dokuda amorf, proteinöz materyal birikimi ile karakterize etyolojisibilinmeyen bir hastalıktır. Amiloid guatr tiroid dokusunun yoğun amiloid birikimi sonucu ortaya çıkan oldukçanadir gözlenen bir durumdur. Amiloid guatr primer ve sekonder sistemik amiloidozla birliktelik göstermekte,daha sıklıkla sekonder sistemik amiloidozla birlikte görülmektedir. Bu durum diğer guatr tiplerinden ve maligndurumlardan ayırt edilmelidir. Amiloidoz varlığı bilinen olgularda bile klinik olarak tanı nadiren öngörülebilir.Kitle etkisine bağlı semptomların giderilmesinde ve tanı konulmasında cerrahi müdahale gereklidir. Burada hızlıbüyüyen guatrı bulunan 21 yaşında bir kadın hasta sunuyoruz. Olgunun tiroidektomi materyalinin histolojikincelemesinde amiloid guatr için tanısal olan ekstrasellüler amiloid birikimi saptanmıştır

Anahtar Kelimeler:

Amiloid guatr, tiroid, amiloidoz

Amyloid Goitre: A Case Report

Amyloidosis is a disease of unknown etiology characterized by the accumulation of an amorphous, proteinaceous material in various organs and tissues of the body.Amyloid goitre is an exceedingly rare pathology due to massive amyloid infiltration of thyroid tissue. Amyloid goitre occurs in association with both primary and secondary systemic amyloidosis, more commonly in the latter. This condition has to be distinguished from other types of goitre and malignancy. The diagnosis is rarely suggested clinically even in the presence of known amyloidosis. Surgical intervention is necessary to relieve the symptoms of neck mass and establish a diagnosis.We present the case of a 21year old female patient who presented with a rapidly enlarging goitre. Histologic examination of the thyroidectomy specimen showed extracellular deposits of amyloid diagnostic of amyloid goitre.

Keywords:

Amyloid goitre, thyroid, amyloidosis,

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