vvvb BATIREL, Serdar ÖZER, Serap GENÇER, Mesut ŞEKER, Mustafa ÇETİNER, Aylin EGEGÜL, Nimet KARADAYI

İmmunkompetan bir hastada ortopedik cerrahi sonrası gelişen transfüzyonla ilişkili graft versus Host hastalığı

Transfüzyonla ilişkili Graft versus Host Hastalığı, genellikle hücresel immünitesi bozulmuş bireylerde histokompatibl olmayan lenfoid hücrelerin transfüzyonu sonrası gelişen, iyi bilinen fakat nadir bir komplikasyondur. İmmünitesi sağlam olan bireylerde de nadiren görülebilir. Ateş, cilt döküntüsü, diyare, karaciğer fonksiyon bozukluğu ve kemik iliği aplazisi bu hastalığın klinik tablosunu oluşturur. Hemen her zaman ölümcül seyreder. Burada, sağ koksartroz nedeniyle ortopedik cerrahi sırasında birinci ve ikinci derece akrabalarından kan transfüzyonu yapılan immünkompetan bir hastadaki ölümcül seyreden Transfüzyonla ilişkili Graft versus Host Hastalığı olgusu sunulmuştur.

Transfusion associated graft-versus-host disease (TA-GVHD) in an immunocompetent patient following orthopedic surgery

Transfusion associated Graft versus Host Disease (TA-GVHD) is a well-known but rare complication that follows infusion of histo-incompatible lymphoid cells, often seen in individuals with impaired cellular immunity. However, it may also occur in immunocompetent individuals. The clinical syndrome consists of fever, skin rash, diarrhea, hepatic dysfunction, and bone marrow aplasia. The outcome is nearly always fatal. We present here a case report of fatal TA-GVHD in a �presumed� immunocompetent patient after transfusion of whole blood from a first and a second degree relative following orthopedic surgery for right coxarthrosis.

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