“Obstrüktif Uyku Apne Sendromunda Gastroduodenal Erozyon ve Peptik Ülser İnsidansı”

Amaç: Bu çalışmada obstrüktif uyku apne sendromu OUAS olan hastalarda mide-duodenum epitelyal hücre hasarı varlığı araştırılmıştır. Yöntem: Çalışmaya orta-ağır OUAS apne-hipopne indeksi >15 tanısı konan 15 hasta ile kontrol grubu oluşturulmak üzere polisomnografi tetkiki normal sonuçlanan apne-hipopne indeksi

Gastroduodenal Erosion and Peptic Ulcer Incidence in Patients with Obstructive Sleep Apnea Syndrome

Aim: The aim of this study was to investigate the gastroduodenal epitelial cell damage in patients with moderate to severe obstructive sleep apnea syndrome. Material and method: Fifteen patient apnea-hipopnea index >15 and 15 control apnea-hipopnea index

___

  • Valle JD. Peptic ulcer disease and related disorders. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrison’s principles of internal medicine (17th edition). New York: McGraw- Hill; 2008:1855-1872.
  • Ramakrishnan K, Salinas RC. Peptic ulcer disease. Am Fam Physician 2007;76:1005-1012.
  • Newton EB, Versland MR, Sepe TE. Giant duodenal ulcers. World J Gastroenterol 2008;14:4995-4999.
  • Aro P, Storskrubb T, Ronkainen J, Bolling-Sternevald E, Engstrand L, Vieth M, Stolte M, Talley NJ, Agréus L. Peptic ulcer disease in a general adult population: the Kalixanda study: a random population-based study. Am J Epidemiol 2006;163:1025-1034.
  • Calam J, Baron JH. ABC of the upper gastrointestinal tract: pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ 2001;323:980-982.
  • Yuan Y, Padol IT, Hunt RH. Peptic ulcer disease today. Nat Clin Pract Gastroenterol Hepatol 2006;3:80-89.
  • Whittle BJ, Lopez-Belmonte J. Actions and interac- tions of endothelins, prostacyclin and nitric oxide in the gastric mucosa. J Physiol Pharmacol 1993;44:91-107.
  • Whittle BJ, Lopez-Belmonte J. Interactions between the vascular peptide endothelin-1 and sensory neu- ropeptides in gastric mucosal injury. Br J Pharmacol 1991;102:950-954.
  • Iaquinto G, Giardullo N, Taccone W, Leandro G, Pasquale L, De Luca L, Szabo S. Role of endogenous endothelin-1 in ethanol-induced gastric mucosal damage in humans. Dig Dis Sci 2003;48:663-669.
  • Tandon R, Khanna HD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ul- cer and gastric carcinoma. Indian J Physiol Pharmacol 2004;48:115-118.
  • Schwartz AR, Patil SP, Laff an AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea. pathogenic mechanisms and therapeutic app- roaches. Proc Am Thorac Soc 2008;5:185-192.
  • White DP. Sleep apnea. Proc Am Thorac Soc 2006;3:124–128.
  • Sanner BM, Konermann M, Sturm A, Müller HJ, Zidek W. Right ventricular dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J 1997;10:2079-2083.
  • Pillar G, Shehadeh N. Abdominal fat and sle- ep apnea: the chicken or the egg? Diabetes Care 2008;31:303-309.
  • p MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169: 348-353.
  • Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med 2004;169:354- 360.
  • Lavie L. Obstructive sleep apnoea syndrome- -an oxidative stres disorder. Sleep Med Rev 2003; 7:35-51.
  • Dyugovskaya L, Lavie P, Lavie L. Increased adhe- sion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 2002;165:934-939.
  • Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, Lam WK. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000;162:2166-2171.
  • Rechtschaff en A, Kales A: A manual of stan- dardized terminology, techniques and scoring system for sleep stages in human subjects. Brain Information Service: Los Angeles, UCLA, 1968.
  • American Academy of Sleep Medicine. Sleep-re- lated breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research; The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999;22:667-689.
  • Silverstein F, Tytgat GNJ. Atlas of gastrointestinal endoscopy. Philadelphia: Saunders; 1987.
  • Megraud F. The CLO test as a reference method for Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2001, 13:1269-1270.
  • Ramakrishnan K, Salinas RC. Peptic ulcer disease. Am Fam Physician 2007;76:1005-1012.
  • Yucel T, Aygin D, Sen S, Yucel O. The prevalence of Helicobacter pylori and related factors among university students in Turkey. Jpn J Infect Dis 2008;61:179-183.
  • Moshkowitz M, Brill S, Konikoff FM, Averbuch M, Arber N, Halpern Z. Additive deleterious eff ect of smoking on gastroduodenal pathology and clinical course in Helicobacter pylori-positive dyspeptic patients. Isr Med Assoc J 2000;2:892-895.
  • Massarrat S. Smoking and gut. Arch Iran Med 2008;11:293-305.
  • Aro P, Storskrubb T, Ronkainen J, Bolling-Sternevald E, Engstrand L, Vieth M, Stolte M, Talley NJ, Agréus L. Peptic ulcer disease in a general adult population: the Kalixanda study: a random population-based study. Am J Epidemiol 2006;163:1025-1034.
  • Watson NF, Mystkowski SK. Aerophagia and gas- troesophageal refl ux disease in patients using continuous positive airway pressure: a preliminary observation. J Clin Sleep Med. 2008 15;4:434-438.
Maltepe Tıp Dergisi-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2009
  • Yayıncı: Maltepe Üniversitesi
Sayıdaki Diğer Makaleler

Periyodik ateş, aftöz stomatit, farenjit ve servikal adenit (PFAPA) sendromlu bir olgu: Tonsillektominin tedavideki etkinliği

Öner ÇELİK, Zerrin BOYACI, M. Öncel KOCA, Hakan KARA

Radyolojik Olarak BI-RADS Kategori 3-5 Olarak Değerlendirilen Meme Lezyonlarının Histopatolojik Değerlendirilmesinde Ultrason Rehberliğinde Yapılan Tru-Cut İğne Biyopsinin Etkinliği: Üç Yıllık Deneyimimiz

Rahmi ÇUBUK, Nuri TASALI, Ahmet MİDİ, Gül ARSLAN, Esra TOZAN BAYRAK, Manuk MANUKYAN, Mehmet ATASOY, Levent ÇELİK, Şefik GÜNEY

“Orta ve Ağır Obstrüktif Uyku Apne Sendromu OUAS Olgularında PAP Positive Airway Pressure Titrasyonuna Objektif ve Subjektif Yanıtın Değerlendirilmesi”

Nesrin SARIMAN, Ender LEVENT, Akın Cem SOYLU, Şirin YURTLU

“Obstrüktif Uyku Apne Sendromunda Gastroduodenal Erozyon ve Peptik Ülser İnsidansı”

Gökhan GÖKÇEN, Yrd.doç.dr.ender LEVENT, Remzi DALAY, Nesrin SARIMAN, Şirin YURTLU, Esen KASAPOĞLU GÜNAL, M.yaşar TÜLBEK

Distal Arkus Anevrizmasında Endovasküler Tedavi: Olgu Sunumu

Mahmut AKYILDIZ, Yılmaz ZORMAN, Esra ERTÜRK, L. Çağatay ONAR, Tamer AKSOY, Harun ARBATLI

80'li Yaşlarda Açık Kalp Cerrahisi Sonrası Yaşam Kalitesinin “Karnofsky Skoru” ile Analizi

Mahmut AKYILDIZ, Tamer AKSOY, Esra ERTÜRK, Yılmaz ZORMAN, Benay ERDEN, Lütfi Çağatay ONAR, Mustafa Serdar YILMAZER, Harun ARBATLI

Seminom ve Budd-Chiary Sendromu Birlikteliği: Olgu Sunumu

Selahattin ŞEKER, Orhan TÜRKEN, Gülçin KIYAN, Mücahit GÖRÜK, Özgün İYİGÜN, Rahmi ÇUBUK, Bülent KARAGÖZ, Oya U. BAYRAMİÇLİ, M.yaşar TÜLBEK

Üriner İnkontinanslı Hastalarda Semptomlarla Ürodinami Bulgularının Karşılaştırılması

Ali Ekber ŞAHİN, Remzi ABALI, Aytaç YÜKSEL, Birtan BORAN, H.serpil BOZKURT, İlkbal TEMEL

Omurga Cerrahisine Anestezi Yaklaşımı - Derleme

Arzu GERÇEK, Serdar ÖZGEN

Petröz Kemik Kolesteatomuna Bağlı İntrakraniyal Komplikasyonlar: Olgu Sunumu

Şevki ŞAHİN, Nilgün ÇINAR, Sunay AYALP, Tuğba OKLUOĞLU, Kübra BATUM, Sibel KARŞIDAĞ