Prediyabet Olan Hastalarda Kardiyovasküler Risk Faktörleri ve Metabolik Sendrom ile İlişkisi

Giriş: Normoglisemik olmayan, ama diyabetik de olmayan yüksek plazma glukozu olarak tanımlanan pre diyabet; komplikasyonlara yol açması nedeniyle dikkat çekicidir. Bu çalışmada; yaş, cinsiyet ve vücut kitle indeksi yönünden eşleştirilmiş prediyabet ve kontrol gruplarında, kardiyovasküler risk faktörleriyle ilişkili parametreleri karşılaştırmayı amaçladık. Hastalar ve Yöntem: Üçüncü basamak bir hastaneden 18-65 yaşları arasındaki hastalar alındı. Prediyabetik olan 74 hasta ile normoglisemik 34 katılımcının olduğu kontrol grubu çalışmaya dahil edildi. Laboratuvar parametreleri, sağlık göstergeleri, insülin direnci, SCORE ve Framingham risk skorları kardiyovasküler risk faktörleri açısından ölçüldü. Bulgular: Total kolesterol, düşük yoğunluklu lipoprotein-kolesterol, yüksek yoğunluklu lipoprotein-koleste rol, trigliseritler, insülin direnci, sigara içme durumu, kan basıncı, SCORE, Framingham risk skoru, bel çev resi, kardiyovasküler durumlar (koroner arter hastalığı, inme, kalp yetmezliği hiperlipidemi, hipertansiyon) iki grup arasında istatistiksel olarak benzerdi. Prediyabetik grupta oral glukoz tolerans testleri (0.,2.), HbA1c ve CRP daha yüksekti. Prediyabetli hastaların metabolik sendrom daha yaygın idi. Prediyabetli katılımcılarda metabolik sendrom varlığını etkileyen bazı sonuçlar regresyon analizleri ile değerlendirildiğinde, obezite ve HDL ilişkili faktörler olarak bulunmuştur. C-reaktif protein ile herhangi bir parametre arasında korelasyon yoktu. Sonuç: Diyabet tedavisinin sayı güdümlü hedeflerinde ve kanıta dayalı yaklaşımda sıklıkla dile getirilen kar diyovasküler risk faktörlerinin diyabetin başlamasından önceki prediyabetik aşamada ortaya çıkabileceğini bildirdik. Ayrıca, bu faktörlerle ilişkili parametreler ve prediyabetin metabolik sendrom ile ilişkisi ortaya konulmuştur.

Cardiovascular Risk Factors in Patients With Prediabetes and its Relationship With Metabolic Syndrome

Introduction: Prediabetes, defined as high plasma glucose which is neither normoglycemic nor diabetic, is noteworthy in that it causes complications. We aimed to reveal cardiovascular risk factors and related pa rameters via comparing prediabetics with age, sex and body mass index-matched control group in this study. Patients and Methods: The patients, aged 18-65 years, were recruited from a tertiary care hospital. A total of 74 patients with prediabetes were included into the study to be compared with the control group of 34 normo glycemic subjects. Laboratory parameters, health indicators, insulin resistance, SCORE and Framingham risk score of participants were measured for cardiovascular risk factors. Results: Total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, insulin resistance, smoking status, blood pressure, SCORE, Framingham risk score, waist circumference, cardio vascular conditions (coronary artery disease, stroke, heart failure, hyperlipidemia, hypertension) were statistically similar between the two groups. Oral glucose tolerance tests (0th, 2nd), HbA1c and CRP were higher in the pre diabetic group. Patients with prediabetes had more common participants with metabolic syndrome. When some outcomes affecting the presence of metabolic syndrome in participants with prediabetics were evaluated by regres sion analyses, obesity and HDL were found to be related factors. There was no correlation between C-reactive protein and any parameter. Conclusion: We report that cardiovascular risk factors, which are often overrated in number-driven targets and evidence-based approach of the treatment of diabetes, may present in the prediabetic stage before the onset of diabetes. In addition, the parameters related to these factors and the relationship of prediabetes with metabolic syndrome were revealed.

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi