İnhale Steroid Kullanmakta Olan ve Tedavilerine Kısa Süreli Sistemik Steroid Eklenen Hastalarda Özefagial Kandidiyazis Prevalansı
Amaç: İnhale steroid kullanmakta olan ve akut atak nedeniyle hastaneye yatırılarak sistemik steroid başlanan astım ve kronik obstrüktif akciğer hastalığı (KOAH) olan hastalarda üst gastrointestinal sistem (GİS) endoskopisi ile özefagial kandidiyazis sıklığını araştırmayı amaçladık. Yöntem: Akut atak nedeniyle hastaneye yatırılmış olan 10 KOAH hastası ve 11 astım hastası çalışmaya alındı (steroid grubu). Bu hastalar en az 1 yıldır inhale steroid kullanmakta idiler. Bu hastalara akut atak tedavisi için günlük 40 mg metil-prednizolon başlandı. Tedavinin 7-10. gününde hastalar stabil hale gelince sistemik steroid kesildi ve üst GİS endoskopisi yapıldı. Beyaz plak görülen hastalardan biyopsi alındı. Gastroenteroloji polikliniğine üst GİS semptomlarıyla başvuran ve malignitesi ya da immünsüpresyonu olmayan grubu olarak çalışmaya alındı. Bulgular: Özefagial kandidiyazis sıklığı steroid grubunda %42.9 ve kontrol grubunda %0.2 olarak bulundu. Sonuç: Uzun süredir inhale steroid kullanan hastalarda özefagial kandidiyazis sıklığı artmaktadır. Bu tedaviye sistemik steroidlerin kısa süreli eklenmesi bu sıklığı artırmaktadır
Prevalance of Esophageal Candidiasis in Patients Treated With Inhaled and Short Course Systemic Steroids
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