Fatma Hilal YILMAZ, Nazlı Dilay GÜLTEKİN, Saime SÜNDÜZ UYGUN, HÜSEYİN ALTUNHAN

İKİ PERİNATAL HİV OLGUSU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Dünya genelinde hâlihazırda yaklaşık 37 milyon

Anahtar Kelimeler:

Fetomaternal enfeksiyon transmisyonu, İnsan immunoyetmezlik virüsü, Yenidoğan

TWO CASES OF PERINATAL HIV AND LITERATURE REVIEW

Already existing in 37 million people worldwide,human immunodeficiency virus (HIV) tends toaffect more people and, thus, it has becomea significant health problem. Turkey is oneof the countries where HIV infection is rarelyseen. Transmission is vertical at %90 of HIV (+)infants and perinatal transmission of HIV hasbeen reduced to less than 1% with the use ofantiretroviral drugs. The risk of complicationsrelated with this prophylactic treatmentmight be accepted when relatively highermorbidity and mortality of HIV infection isconsidered. Meanwhile close follow-up ofpatients is required due to possible toxicity.The transmission of HIV into newborns can beprevented with appropriate management ofthe perinatal period. This report describes theperinatal management of two newborns thatwere delivered by HIV (+) mothers.

Keywords:

Fetomaternal infection transmission, human immunodeficiency virus, newborn,

PDF

___

1. World Health Organization (2015) Media Centre. HIV/ AIDS Fact Sheet No 360. http://www.who.int/mediacentre/ factsheets/fs360/ en/. Accessed 25 April 2016
2. UNAIDS 2009 AIDS epidemic update. http://www.who.int/hiv/pub/epidemiology/epidemic/en/
3. HIV Among Women. Fast Facts. Centers for Disease Control and Prevention. https://www.cdc.gov/hiv/group/gender/ women/.
4. Dökmetaş İ, Hamidi AA. HIV- Epidemiyoloji. Turkiye Klinikleri J Inf Dis-Special Topics 2016;9(1):6-11
5. Forbes JC, Alimenti AM, Singer J et al. A nationalreview of vertical HIV transmission. AIDS. 2012; 26(6): 757–63.
6. Sütçü M, Aktürk H, Somer A, Hançerli Törün S, İnce Z, Çoban A, et al. Mother-to-child transmisson of.HIV: an eight-year experience. Mikrobiyol Bul 2015;49:542-53.
7. UNAIDS. 2013. Global report: UNAIDS report on theglobal AIDS epidemic 2013. Joint United Nations Programme on HIV/AIDS, Geneva, Switzerland. http://www.unaids.org/sites/ default/files/media_asset/UNAIDS_Global_Report_2013_en_1. pdf
8. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal– infant transmission of humanimmuno deficiency virüs type 1 with zidovudine treatment. N Engl J Med 1994;331:1173-80.
9. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Rockville, MD: AIDS info; 2016. ( http://aidsinfo.nih.gov/contentfiles/lvguidelines/PerinatalGL. pdf)
10. M.G. Fowler, M. Qin, S.A. Fiscuset al. Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention. N Engl J Med 2016;375:1726-37
11. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States 2014 [cited 6 June 2014]. Available: http://aidsinfo.nih.gov/contentfiles/lvguidelines/ PerinatalGL.pdf.
12. Mandelbrot L, Landreau-Mascaro A, Rekacewicz C et al. Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA. 2001; 285 (16): 2083–93.
13. Nielsen-Saines K, Watts DH, Veloso VG et al. Three postpartum antiretroviral regimens to prevent intrapartum HIV infection. N Engl J Med. 2012; 366(25): 2368–79.
14. Hanson IC, Shearer WT. Diagnosis of HIV infection. Semin Pediatr InfectDis 1994; 5: 266-71 156