ÇÖLYAK HASTASI ÇOCUKLARDA GLUTENSİZ DİYETİN HEMATOLOJİK PARAMETRELER ÜZERİNDEKİ ETKİLERİ

AMAÇ: Çölyak hastalıklı çocuklarda glutensiz diyetin hematolojik

Anahtar Kelimeler:

Çölyak hastalığı, Anemi, Trombositoz, Ortalama platelet hacmi

EFFECTS OF GLUTEN-FREE DIET ON HEMATOLOGICAL PARAMETERS IN CHILDREN WITH CELIAC DISEASE

OBJECTIVE: This study aims to evaluate the effects onhematological parameters of the gluten-free diet inceliac disease children.MATERIAL AND METHODS: Firstly, children with celiacdisease were identified in our clinic. Then, retrospectively,among these patients who were able to performgluten-free diet correctly were specified. Hematologicalparameters of these patients were compared during thediagnosis and 6 months after the gluten-free diet.RESULTS: Sixty-seven of 97 children with celiac diseasewere included in the study. Forty-four patients werefemale (66.7%), 22 patients were male (33.3%) and themean age of diagnosis was 7.1 ± 4.2 years. The most commonhematologic disorders in patients were thrombocytosisin 38 patients (57.5%) and anemia in 28 patients(42.2%). Twenty-four patients with anemia (36.6%) hadiron deficiency anemia, two patients with anemia (3%)had folate deficiency and one patient with anemia (1.5%)had vitamin B12 deficiency. After 6 months of gluten-freediet, only 8 patients (13%) had anemia. After the gluten-free diet, platelet counts decreased from 351.2 ± 11.0(103 / μL) to 310.5 ± 82.0 (103 / μL), leukocyte count decreasedfrom 8.82 ± 3.04 (103 / μL) to 8.04 ± 2.56 and meanplatelet volume decreased from 10.08 ± 1.07 fl to 9.5 ±1.19 fl. It was determined that there was a significant increasein hemoglobin, mean corpuscular volume and redcell distribution width values.CONCLUSIONS: The most common hematologicalfindings in children with celiac disease are thrombocytosisand anemia. An improvement has been observedin anemia after gluten-free diet. In addition, manyhemostasis parameters have been improved with thegluten-free diet.

Keywords:

Celiac disease, anemia, thrombocytosis, mean platelet volume,

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