Sol Koroner Arter Bifurkasyon Açısı ve Sol Ana Koroner Arter Uzunluğunun Aterosklerotik Plak Yükü Üzerine Etkisi

ÖZ GİRİŞ ve AMAÇ: Koroner arter hastalığı (KAH) önemli bir halk sağlığı sorunudur. Gensini skorlama sistemi (GS) klinik pratikte ateroskleroz yükü, KAH yaygınlığı ve ciddiyetini belirlemede kullanılan en popüler skorlama yöntemlerinden birisidir. Daha önce yapılmış çalışmalarda geniş açılanma ile ciddi koroner arter darlığı arasında korelasyon olduğu gösterilmiştir. Bu çalışmada, koroner arter bifurkasyon açısı ve LMCA uzunluğunun koroner aterosklerotik yük ile ilişkini incelemeyi amaçladık. YÖNTEM ve GEREÇLER: Koroner anjiografi yapılan hastalar incelendi. Akut koroner sendromu, normal koroner arterleri, LMCA osteal lezyonu, LAD osteal lezyonu, CX osteal lezyonu, bifurkasyon açısının ölçümü için yeterli görüntüleme yapılamamış olan hastalar dışlandı. 2 deneyimli kardiyolog tarafından "extreme pacs" yazılım sistemi kullanılarak çalışmaya dahil edilen hastaların LAD-CX bifurkasyon açısı ve LMCA uzunluğu ölçüldü. Dahil edilen hastaların aterosklerotik plak yükü GS kullanılarak hesaplandı. BULGULAR: 63 hasta (36 erkek, 27 kadın) çalışmaya dahil edildi. LAD-Cx bifurkasyon açısı ile gensini skoru arasında kuvvetli pozitif korelasyon mevcuttu (r= 0,854; p

Effect of Left Coronary Bifurcation Angle and Left Main Coronary Artery Length on Coronary Artherosclerotic Plaque Burden

ABSTRACTINTRODUCTION: Coronary artery disease (CAD) is animportant public health problem. The Gensini score system(GS) is one of the most popular coronary scoring systems usedin clinical practice to determine the atherosclerotic burden,extent and severity of CAD. Previous studies have showed thedirect correlation between wide angulation and significantcoronary stenosis. In this study we analysed the effect ofcoronary bifurcation angle and left main coronary artery(LMCA) length on the coronary atherosclerotic burden.METHODS: Patients, who underwent coronary angiographywere scanned. Patients having; acute coronary syndrome,normal coronary arteries, LMCA lesion, osteal left anteriordescending (LAD) coronary artery lesion, osteal circumflex(CX) coronary artery lesion, inadequate visualisation forbifurcation angle measurement were excluded. LAD-CXcoronary artery bifurcation angle and LMCA length ofincluded patients were analysed by 2 experienced cardiologistsby using "extreme pacs" software system. Atheroscleroticburden of included patients were determined by GS.RESULTS: 63 patients (36 male, 27 female) were included.There was a strong positive correlation between LAD-CXbifurcation angle and gensini score (r= 0,854; p

___

  • 1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. The global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. TheLancet. 2006; 367(9524):1747-57.
  • 2. Hansen T, Kilander L, Ahlström H, Lind L. Total atherosclerotic burden measured by magnetic resonance imaging is related to a five-year decline in cognitive function. Clin Physiol Funct Imaging. 2018 May;38(3):373-377
  • 3. Geraci G, Buccheri D, Zanoli L, Fatuzzo P, DiNatale K, Zammuto MM, Nardi E, Geraci C, Mancia E, Zambelli G, Piraino D, Signorelli SS, Granata A, Cottone S, Mule G. Renal haemodynamics and coronary atherosclerotic burden area associated in patients with hypertension and mild coronary artery disease. Exp Ther Med. 2019 Apr;17(4):3255-3263.
  • 4. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
  • 5. Caro C G, Fitz-Gerald J. M and Schroter R. C (1971). Atheroma and arterial wall shear observation, correlation, and proposal of a sheardependent mass transfer mechanism for atherogenesis. Proc. R. Soc. Lond. B Biol. Sci. 177, 109–133.
  • 6. Stewart Dowding, Constantine Zakkaroff, Stephen Moore and Tim David. Coronary Smooth Muscle Cell Calcium Dynamics: Effects of Bifurcation angle on atheroprone conditions. Frontiers in physiology. 2018;9: 1-13. doi: 10.3389/fphys.2018.01528.
  • 7. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 2012;51:606
  • 8. Hackman DG, Anand SS. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA. 2003 Aug 20; 290(7):932- 40
  • 9. Cunningham KS, Gotlieb AI. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest. 2005 Jan;85(1):9-23.
  • 10. Zhonghua Sun, Thanapong Chaichana. An investigation of the correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational Fluid Dynamics. Quant Imaging Med Surg 2017;7(5):537-548
  • 11. A. Tedgui and Z. Mallat, “Cytokines in atherosclerosis: pathogenic and regulatory pathways,” Physiological Reviews, vol. 86, no. 2, pp. 515–581, 2006
  • 12. Chiu, J. J., and Chien, S. (2011). Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol. Rev. 91, 327–387. doi: 10.1152/physrev.00047.2009
  • 13. Lauric A, Hippelheuser JE, Malek AM. Induction of aneurysmogenic high positive wall shear stress gradient by the wide angle at cerebral bifurcations, independent of flow rate. J Neurosurg. 2018 Aug 1:1-11. doi: 10.3171/2018.3.JNS173128
  • 14. Tütüncü F, Schimansky S, Baharoglu MI, Gao B, Calnan D, Hippelheuser J, Safain MG, Lauric A, Malek AM. Widening of the basilar bifurcation angle: association with the presence of an intracranial aneurysm, age, and female sex. J Neurosurg. 2014 Dec;121(6):1401-10. doi: 10.3171/2014.8.JNS1447
  • 15. Thomas, J. B., Antiga, L., Che, S. L., Milner, J. S., Steinman, D. A. H., Spence, J. D., et al. (2005). Variation in the carotid bifurcation geometry of young versus older adults: Implications for geometric risk of atherosclerosis. Stroke 36, 2450– 2456. doi: 10.1161/01.STR.0000185679.62634.0a
  • 16. Cui Y, Zeng W, Yu J, Lu J, Hu Y, Diao N, Liang B, Han P, Shi H. Quantification of left coronary bifurcation angles and plaques by coronary computed tomography angiography for prediction of significant coronary stenosis: A preliminary study with dual-source CT. PLoS One. 2017 Mar 27;12(3):e0174352. doi:
  • 10.1371/journal.pone.0174352. collection 2017. 17. Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, et al. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis 1997;129:111-8.
  • 18. Zhou F., Liu Y, Ge P C, Chen Z, Ding X, Liu J, Jia Q, An F, Li L, Wang L, Ma W, Yang Z, Jia E. Coronary Artery Diameter is Inversely Associated with the Severity of Coronary Lesions in Patients Undergoing Coronary Angiography. Cell Physiol Biochem 2017;43:1247–1257
  • 19. N Gazetopoulos, PJ Ioannidis, C Karydis, C Lolas, K Kiriakou, and C Tountas. Short left coronary artery trunk as a risk factor in the development of coronary atherosclerosis. Pathological study. Br Heart J. 1976 Nov; 38(11): 1160–1165.
Kocaeli Tıp Dergisi-Cover
  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
Sayıdaki Diğer Makaleler

Chronic Obstructive Lung Disease Frequency in Colorectal Polyp and Relationship with Systemic Inflammation

Şule TAŞ GÜLEN, Onur YAZICI, Altay KANDEMİR

DRESS Syndrome in Patient with Diagnosis of Meningitis; Case Report

Gülten ÜNLÜ, Şemsi Nur KARABELA, Emine DÜNDAR, Kadriye KART YAŞAR

İlerleyen Yaşta Pelvik Taban Bozukluğu

Gökmen SUKGEN, Ünal TÜRKAY

Mean Platelet Volume and Renal İnvolvement in Patients with Systemic Lupus Erythematosus

Gökhan SARGIN, Taşkın ŞENTÜRK

Simple and New Echocardiographic Parameter Related to Aging: Descending Aortic Continuous Wave Doppler Systolic Peak Gradient

Onur ARGAN, Serdar BOZYEL

Kalp Cerrahisinde Postoperatif Perikardiyal Efüzyonun Önlenmesi İçin Posterior Perikardiyal Pencere Tekniği

Mehmet EZELSOY, Kemal Tolga SARAÇOĞLU, Kerem ORAL, Belhan AKPINAR, Ayten SARAÇOĞLU

Girişimsel Kardiyologlar Arasında Atriyal Fibrilasyon Farkındalık Anketi Değerlendirmesi

Cengiz BURAK, Muhammed SÜLEYMANOĞLU, Serhat HAYME, Erkan BAYSAL, İlyas KAYA, Bernas ALTINTAŞ, Serhat GÜNLÜ

Splenik Arter Psödoanevrizmasının Senkop ile Kendini Gösteren Rüptür Sonrasında Rekürrensi: Transarteriyel Embolizasyon ile Tedavi

Fatih UZUNKAYA, Ayşegül İdil SOYLU, Mehmet Selim Nural, Kağan KARABULUT

Posterior Pericardial Window Technique to Prevent Postoperative Pericardial Effusion in Cardiac Surgery

Mehmet EZELSOY, Kerem ORAL, Kemal Tolga SARAÇOĞLU, Ayten SARAÇOĞLU, Belhan AKPINAR

Efficiency and Midterm Results of Glue Ablation with Cyanoacrylate and Endovenous Thermal Ablation with Radiofrequency of Great Saphenous Vein Under Warfarin Therapy

Emin CANTÜRK