Mean Platelet Volume and Renal İnvolvement in Patients with Systemic Lupus Erythematosus

ABSTRACT INTRODUCTION: Our aim is to determine the relationship between mean platelet volume (MPV) and renal involvement in patients with systemic lupus erythematosus (SLE). We also aimed to evaluate erythrocyte sedimentation rate (ESR), Creactive protein (CRP), complement component 3 (C3), C4, and disease activity at the baseline and 6th months of treatment in SLE patients with renal involvement. METHODS: A total of 85 SLE patients (4 male, 81 female, with the mean age of 39,5±10,5 years) who had been diagnosed with SLE were enrolled in the study. Age, gender, MPV, CRP, ESR, C3, C4, and SLE Disease Activity Index (SLEDAI) were evaluated. The data were assessed with Kolmogorov-Smirnov, Mann-Whitney, Wilcoxon test, and Spearman correlation. RESULTS: The levels of MPV were higher in patients without nephritis compared to patients with nephritis. There was no significant difference in MPV between both groups. We found a correlation between MPV and disease activity for SLE patients with renal involvement and without renal involvement (r=- 0,396, p=0.04, r=-0.278, p=0.03, respectively). DISCUSSION and CONCLUSION: MPV is negatively correlated with disease activity in lupus patients with renal involvement and without renal involvement. MPV may be helpful to assess disease activity and organ-involvement in patients with SLE. the knowledge about long-term results about this topic is limited.

Sistemik Lupus Eritematozlu Hastalarda Böbrek Tutulumu ve Ortalama Trombosit Hacmi

ÖZ Amaç: Amacımız, sistemik lupus eritematozuslu (SLE) hastalarda ortalama trombosit hacmi (MPV) ile renal tutulum arasındaki ilişkiyi belirlemektir. Ayrıca renal tutulumlu SLE hastalarında eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), kompleman bileşen 3 (C3), C4 ve hastalık aktivitesini başlangıçta ve tedavinin 6. ayında değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmaya SLE tanısı almış 85 hasta (4 erkek, 81 kadın, ortalama yaş 39,5±10,5 yıl) alındı. Yaş, cinsiyet, MPV, CRP, ESH, C3, C4 ve SLE hastalık aktivite indeksi (SLEDAI) değerlendirildi. Veriler KolmogorovSmirnov, Mann-Whitney, Wilcoxon testi ve Spearman korelasyonu ile değerlendirildi. Bulgular: MPV düzeyi, nefriti olmayan hastalarda nefriti olan hastalara göre daha yüksekti. Her iki grup arasında MPV açısından anlamlı farklılık yoktu. Böbrek tutulumu olan ve böbrek tutulumu olmayan SLE hastalarında MPV ile hastalık aktivitesi arasında korelasyon saptandı (sırasıyla, r=-0,396, p=0,04, r=-0,262, p=0,03). Sonuç: Böbrek tutulum olan ve olmayan lupus hastalarında hastalık aktivitesi ile MPV negatif korelasyon göstermektedir. MPV, SLE'li hastalarda hastalık aktivitesini ve organ tutulumunu değerlendirmede yardımcı olabilir. Yinede, bu konuyla ilgili uzun dönem sonuçları hakkında bilgiler sınırlıdır.

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Kocaeli Tıp Dergisi-Cover
  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -