Ekstübasyon Sonrası Görülen Kardiyovasküler ve Solunum Sistemi Yanıtlarına Benzidamin ve Lidokain'in Etkileri

GİRİŞ ve AMAÇ: Endotrakeal tüp kafının (ETT) üzerine benzidamin sprey uygulanması, ameliyat sonrası boğaz ağrısı oranını azaltır. Bu uygulamanın etkinliği, bu amaçla yaygın olarak kullanılan intravenöz lidokain ile karşılaştırılmamıştır. Bu çalışmamızda; entübasyon öncesi endotrakeal tüp kafı çevresine uygulanan benzidaminin ve intravenöz yoldan lidokainin ekstübasyona bağlı kardiyovasküler ve solunum sistemlerinde gelişebilecek olumsuz yanıtlara etkileri araştırıldı. YÖNTEM ve GEREÇLER: İki yüz hasta rastgele 4 gruba ayrıldı (her birinde n = 50). Kontrol grubuna (Grup C) ekstübasyondan 5 dakika önce intravenöz (iv) salin, lidokain grubuna (Grup L) 1,5 mg.kg-1 iv lidokain uygulandı. Benzidamin grubuna (Grup B) ve lidokain-benzidamin grubuna (Grup LB) entübasyondan önce ETT'lerine benzidamin sprey uygulandı, ekstübasyondan 5 dakika önce sırasıyla iv salin ve 1.5 mg.kg-1 iv lidokain uygulandı. Ekstübasyon (1-30 dk) sonrası hemodinamik parametreler ve postoperatif 1-72 saat boğaz ağrısı, öksürük, ses kısıklığı kaydedildi. BULGULAR: Demografik veriler tüm gruplarda benzerdi. Kalp hızındaki artış B ve LB gruplarında C ve L gruplarına göre daha düşüktü (p

Effects of Benzydamine and Lidocaine on Cardiovascular and Respiratory Responses to Extubation

INTRODUCTION: Benzydamine spray of endotracheal tube cuff (ETTc) supresses postoperative sore throat rate. Efficiency of this practice has not been compared to the common practice of intravenous lidocaine application. Present study aims to compare the efficiency of these practices. METHODS: Two hundred patients were randomized into 4 groups (n=50, in each). Control group (Group C) had iv saline, lidocaine group (Group L) had 1.5 mg.kg-1 iv lidocaine 5 min before extubation. Benzydamine group (Group B) and lidocaine-benzydamine group (Group LB) had their ETTc sprayed with benzydamine before the intubation, iv saline and 1.5 mg.kg-1 iv lidocaine was administered 5 min before the extubation respectively. Hemodynamic parameters after the extubation (1-30 min) and sore throat, coughing, hoarseness at the postoperative 1-72 hrs were recorded. RESULTS: Demographic data were similar. The increase in heart rate was lower in groups B and LB compared to groups C and L (p

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