Tip 2 Diabetes Mellitusta Kullanılan Bitkisel Ürünler: Sistematik Derleme
Giriş: Doğa, antidiyabetik ilaçların olağanüstü bir kaynağıdır. Günümüzde 1200'den fazla çiçekli bitkinin antidiyabetik özelliği olduğu iddia edilmektedir. Tip 2 diabetes mellitus (T2DM) tedavisinde son yıllarda tamamlayıcı terapilerin kullanımı giderek artmaktadır. Bu sistematik derlemenin amacı, T2DM tanılı bireylerin tıbbi tedavilerinin yanında hastalık yönetiminde kullandıkları bitkisel ürünlerle ilgili yapılmış olan randomize kontrollü çalışmaları incelemektir. Yöntem: Derlemeye 2000-2016 yılları arasında yapılan çalışmalar alınmıştır. Derleme Ocak 2017 tarihinde; anahtar kelimeleri Türkçe literatürde“T2DM, bitkisel ürünler, randomize kontrollü”, İngilizce literatürde“T2DM, complemantary therapies and randomised controlled trial” anahtar kelimeleri kullanılarak yapılmıştır. Yapılan çalışmada "Science citation index (43), Directory of Open Access Journals (16), Academic One File (15), Scobus (10), Social Sciences Citation Index (7), CINAHL Complete (10), Medline (5), Science Direct (5), Academic Search Complete (3), General One File (2) ve Google Academic (10)"den ulaşılan, tam metin olarak yayınlanan makaleler analiz edilmiştir. Bulgular: İncelenen bitkisel ürünlerden 11’i ile (tarçın, resveretrol, deve dikeni, kothala himbutu çayı, demir otu, goshajinkian (Geleneksel Japon şifalı bitkileri), geleneksel Nijerya çayı, ayurvedic bitkisel ürün karışımı, jinlida (geleneksel Çin terapisi ) ve TM81 (Çin Bitkisel karışımı), zencefil) yapılan çalışmalarda plesebo grubuna göre FPG ve HbA1c’de önemli düzeyde düşmenin olduğu ortaya konmuştur. Yedi bitkisel ürünün ise (tarçın, deve dikeni, yeşil çay ve ebegümeci çayı, satureja khuzestanica (endemik İran bitkisi), demir otu, brokoli filizi tozu) kan lipidlerini düşürücü etkilerinin anlamlı olduğu görülmüştür. Sonuç: T2DM için bir tedavi seçeneği olarak bitkisel ürünlerin etkililiğini destekleyen kanıtlar yetersizdir. Bitkisel ürünlerin etkinliğini ortaya çıkaracak daha fazla çalışmaya gereksinim olduğu belirlenmiştir. Bitkisel ürünleri kullanan T2DM tanılı bireylerin güvenliğini sağlamak için, sağlık personelleri etkili iletişimde bulunmalı, bitkisel ürünlerin, etkinliklerinin ve yan etkilerinin farkında olmalıdır.
Herbal Therapies Used in Type 2 Diabetes Mellitus: A Systematic Review
Introduction: Nature is a miracle source for medicine to treat diabetes. Recently, more than 1,200 flowers have been discovered to have anti-diabetes properties. In the treatment of type 2 diabetes mellitus (T2DM), the use of these complementary therapies has increased. The aim of this systematic review is to analyze randomized control group studies on herbal therapies which individuals have used to complement conventional treatments. Method: This systematic review consists of studies that were conducted between 2000 and 2016. This systematic review, conducted in January 2017, was based on using the keywords “type 2 diabetes mellitus, complementary therapies and randomized controlled trial.” Full articles were accessed and systematically reviewed from the following sources: Science Citation Index (43), Directory of Open Access Journals (16), Academic One File (15), Scobus (10), Social Sciences Citation Index (7), CINAHL Complete (10), Medline (5), Science Direct (5), Academic Search Complete (3), General One File (2), and Google Academic (10). Results: In the studies conducted with eleven herbal products (cinnamon, resveratrol, silybummarianum, salacia reticulata, vernonia cinerea, goshajinkigan, Rauvolfia-Citrus tea, pancreas tonic (an ayurvedic herbal supplement), the Chinese herbal medicine jinlida, and TM81 (tang-min-ling-wan) ginger, it was found that there was a significant decrease in FBG and HbA1c from the placebo groups. However, in the seven studies systematically reviewed, seven herbal products (cinnamon, milk thistle, green tea, sour tea, satureja khuzestanica, vernonia cinerea, and broccoli shrouds powder) were found to cause a significant decrease in blood lipids effectively. Conclusion: The evidence supporting the effectiveness of herbal products as a treatment choice for T2DM are insufficient. It was determined that more studies to prove the effectiveness of herbal products are necessary. In order to support the safety of individuals with T2DM using herbal products, healthcare professionals should interact with them effectively and be aware of the side effects of herbal products.
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