Hipertansiyon Rozasea Hastaları İçin Risk Mi?

Amaç: Rozasea genetik ve çevresel faktörlerin etkisiyle özellikle yüzün orta bölgesinde gelişen, yaygın, kronik enflamatuvar bir dermatozdur. Kronik enflamasyonun hipertansiyon başta olmak üzere kardiyovasküler hastalıkların gelişimindeki rolü bilinmektedir. Bu çalışmada rozasea hastalarında hipertansiyon araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya 73 rozasea hastası ve 70 gönüllü dâhil edildi. Rozasea ve kontrol grubundaki hastaların demografik özellikleri, özgeçmiş bilgileri ve eşlik eden hastalıkları kayıt altına alındı. Rozasea tanısı için Amerikan Ulusal Rozasea Derneği tarafından geliştirilen, tanı koyma ve araştırmalar sırasında kullanılabilen standart sınıflama kullanıldı. Çalışma grubunun dermatolojik muayeneleri sırasında ve muayeneden 2 hafta sonra tansiyonları ölçüldü ve ortalama değerler not edildi. Bulgular: Çalışmaya katılan 73 rozasea hastasından 17’si (%23.2) ve kontrol grubunu oluşturan 70 hastadan 12’si (%17.1) daha önceden hipertansiyon (HT) tanısı ile takip edilen hastalardan oluşmaktaydı. Tanı konmuş HT sıklığı hasta grubunda kontrol grubuna göre istatistiksel olarak daha yüksek olarak saptandı. Hasta ve kontrol grubunun ölçülen ortalama kan basınçları arasında ise istatistiksel fark bulunmadı. Sonuç: Bu çalışmada elde ettiğimiz rozasea hasta grubunda yüksek HT sıklığı literatürlü uyumlu idi. Kronik enflamasyonla seyreden dermatolojik hastalıklarda kardiyovasküler komorbiditelerin klinisyen tarafından göz önünde bulundurulması gereken bir durum olduğunu düşünmekteyiz.unu düşünmekteyiz.

Anahtar Kelimeler:

Rozasea, Hipertansiyon, Kardiyovasküler Hastalık

Is Hypertension a Risk for Rosacea Patients?

Objective: Rosacea is a common, chronic inflammatory dermatosis that develops especially in the middle region of the face under the influence of genetic and environmental factors. The role of chronic inflammation in the development of cardiovascular diseases, especially hypertension, is known. In this study, it was aimed to investigate hypertension in patients with rosacea. Materials and Methods: 73 rosacea patients and 70 volunteers were included in the study. Demographic characteristics, history and accompanying diseases of the patients in the rosacea and control group were recorded. For the diagnosis of rosacea, the standard classification developed by the American National Rosacea Society and used during diagnosis and research was used. During the dermatological examinations of the study group and 2 weeks after the examination, blood pressure was measured and the mean values were noted. Results: Seventeen (23.2%) of the 73 rosacea patients included in the study and 12 (17.1%) of the 70 patients in the control group consisted of patients who had been followed up with a previous diagnosis of hypertension (HT). The frequency of diagnosed HT was found to be statistically higher in the patient group than in the control group. There was no statistical difference between the measured mean blood pressure values of the patient and control groups. Conclusion: The high frequency of HT in the rosacea patient group we obtained in this study was compatible with the literature. We think that cardiovascular comorbidities in dermatological diseases with chronic inflammation should be considered by the clinician.n.

Keywords:

Rosacea, Hypertension, Cardiovascular Disease,

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Spoendlin J, Karatas G, Furlano RI, Jick SS, Meier CR. Rosacea in patients with ulcerative colitis and crohn's disease: A population-based case-control study. Inflamm Bowel Dis. 2016;22(3):680-687.
Belli AA, Gok SO, Akbaba G, Etgu F, Dogan G. The Relationship between rosacea and insulin resistance and metabolic syndrome. Eur J Dermatol. 2016;26(3):260-264.
Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Exploring the association between rosacea and parkinson disease: A danish nationwide cohort study. JAMA Neurol. 2016;73(5):529-534
Baima B, Sticterling M. Demodicidosis revisited. Acta Derm Venerol 2002;82:3-6.
Değerli K, Kutuk N, Limoncu ME, Girgin Kardeşler N, Ozbakkaloğlu B, Ok UZ ve ark. Acne rosacea on tanılı Hastalarda D. folliculorum insidansı ve buna eşlik eden Bakteri turleri. Turkiye Parazitol Derg 1998;22:383-385.
Forton F, Seys B. Density of Demodex folliculorum in Rosacea: A case control study using standardized skin-surface biopsy. Br J Dermatol 1993;128:650-659.
Kyriakis, KP, Palamaras, I, Terzoudi, Emmanuelides SS, Michailides C, Pagana G. Epidemiologic aspects of rosacea. J Am Acad Dermatol. 2005;53(5):918-919.
Del Rosso JQ. Advances in understanding and managing rosacea: Part 1: Connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema. J Clin Aesthet Dermatol. 2012;5(3):16-25.
Gomaa, AH, Yaar M, Eyada MM, Bhawan J. Lymphangiogenesis and angiogenesis in non-phymatous rosacea. J Cutan Pathol. 2007;34(10):748-753.
Smith JR, Lanier VB, Braziel RM, Falkenhagen KM, White C, Rosenbaum JT. Expression of vascular endothelial growth factor and its receptors in rosacea. Br J Ophthalmol. 2007;91(2):226-229.
Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Assessment of the risk of cardiovascular disease in patients with rosacea. J Am Acad Dermatol. 2016;75(2):336-339.
Wilkin, J, Dahl, M, Detmar M, Drake L, Liang MH, Odom R et al. Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol. 2004;50(6):907-912.
Aydoğdu S, Güler K, Bayram F, Altun B, Derici Ü, Abacı A ve ark. Turkish Hypertension Consensus Report. Turk Kardiyol Dern Ars 2019, 47(6):535-546.
Hua TC, Chung PI, Chen YJ, Wu LC, Chen YD, Hwang CY et al. Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from taiwan. J Am Acad Dermatol. 2015;73(2):249-254.
Rainer BM, Fischer AH, da Silva DLF, Kang S, Chien AL. Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: Results of a case-control study. J Am Acad Dermatol. 2015;73(4):604-608.
Egeberg A, Fowler JF, Gislason GH, Thyssen JP et al. Nationwide assessment of cause-specific mortality in patients with rosacea: A cohort study in Denmark. Am J Clin Dermatol. 2016;17(6):673-679.
Son JH, Chung BY, Jung MJ, Choi YW, Kim HO, Park CW. The risk of rosacea according to chronic diseases and medications: A 5-year retrospective, multi-ınstitutional case-control study. Ann Dermatol. 2018;30(6):676-687.
Chen Q, Shi X, Tang Y, Wang B, Xie HF, Shi W, Li J. Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis. J Am Acad Dermatol. 2020;83(5):1331-1340.
Tsai TY, Chiang YY, Huang YC. Cardiovascular risk and comorbidities in patients with rosacea: A systematic review and meta-analysis. Acta Derm Venereol. 2020 Oct 21;100(17):adv00300.