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Hashimoto Tiroidit’i ile Papiller Tiroid Karsinom Birlikteliği ve Prognoza Etkileri

Tiroidit, tiroid glandının inflamasyonu ile karakterize, çeşitli hastalıkları içeren genel bir terimdir. Hashimoto tiroiditi, en sık görülen otoimmun tiroid hastalığıdır ve son yıllarda insidansı giderek artmaktadır. Papiller tiroid kanseri ise en sık görülen tiroid kanseri olup Hashimo tiroiditi zemininde genel popülasyona göre daha sık görülmektedir. Hashimoto tiroiditi ile papiller tiroid karsinomu arasındaki ilişki ilk olarak 1955 yılında Dailey ve ark tarafından ortaya atıldığından beri bununla ilgili tartışmalar ve araştırmalar hala devam etmektedir. Hashimoto tiroiditi ve papiller tiroid karsinomu birlikte görülme insidansı literatüre göre %0.5 ile %41.4 arasında değişmekte olup ortalama yaş daha düşük bulunmuştur. Hashimoto tiroiditi ve papiller tiroid karsinom birlikteliğinin koruyucu bir etki gösterdiği, Hashimoto tiroiditi ile birlikte olan papiller tiroid karsinomunun daha az agresif, tümörün daha küçük ve daha sıklıkla multifokal olduğu, daha az lenf nod invazyonu gösterdiği bildirilmiştir. Hashimoto tiroiditi zemininde, multifokal alanlarda izlenen, displastik tirosit gruplarındaki papiller tiroid karsinomu ilişkili gen aktivasyonları, Hashimoto tiroiditi-papiller tiroid karsinom birlikteliği ve multifokaliteden sorumlu tutulabilir.noz, Tiroidit.

Anahtar Kelimeler:

hashimoto thyroiditis, papillary thyroid carcinoma, prognosis, thyroiditis

Coexistence of Hashimoto’s Thyroiditis With Papillary Thyroid Carcinoma and Its Effects on Prognosis

Thyroiditis is a general term that includes various diseases characterized by inflammation of the thyroid gland. Hashimoto’s thyroiditis is the most common autoimmune thyroid disease and its incidence has been increasing in recent years. Papillary thyroid cancer is the most common thyroid cancer, and it is more common with HT than in the general population. Since the relationship between Hashimoto’s thyroiditis and papillary thyroid cancer was first put forward by Dailey et al. in 1955, discussions and research on this issue still continue. The incidence of co-occurrence of Hashimoto’s thyroiditis and papillary thyroid cancer varies between 0.5% and 41.4% according to the literature, and the mean age has been found lower. It has been reported that the combination of Hashimoto’s thyroiditis and papillary thyroid cancer has a protective effect, papillary thyroid cancer with Hashimoto’s thyroiditis is less aggressive, the tumor is smaller and more often multifocal, and has less lymph node invasion. Papillary thyroid cancer related gene activations in dysplastic thyrocyte groups observed in multifocal areas in the background of Hashimoto’s thyroiditis may be responsible for Hashimoto’s thyroiditis- papillary thyroid cancer association and multifocality.

Keywords:

Hashimoto thyroiditis, Papillary thyroid carcinoma, Prognosis, Thyroiditis,

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