Obezitede İnflamasyon ve İnsülin Direncine Etkili Hematolojik ve İnflamatuar Parametreler

Amaç: Obezite; insülin direnci, tip 2 diyabet ve pek çok metabolik sendromun altında yatan baskın risk faktörlerinden biridir. Bu çalışmada obez hastalarda inflamasyon parametrelerini, bu parametrelerin insülin direnci (İD) ve kan grupları ile ilişkisi araştırmayı amaçladık. Gereç ve Yöntemler: Hasta ve kontrol grubunun demografik özellikleri, vücut kitle indeksleri (VKİ), biyokimya, hemogram, C-reaktif proteinin (CRP) ve kan grupları kayıt edilerek gruplar arasında karşılaştırıldı. Bulgular: Obez hastaların yaş ortalaması 37.37±11.43 yıldı ve %41.8’inde (n=77) insülin direnci vardı. Obez ve İD olan grubun nötrofil ve monosit düzeyleri İD olmayan kontrol ve obez gruplardan anlamlı derecede yüksekti (p<0.001). İD olan obezlerde nötrofil/lenfosit oranı (NLO), monosit/HDL oranı (MHO) ve sistemik immün-inflamatuar indeks (Sİİ) düzeyleri İD olamayan obezlerden anlamlı derecede yüksekti. B kan grubunda olan obezlerde İD ve nötrofil oranları O kan grubundakilere göre anlamlı derecede yüksek bulundu (p=0.023). Sonuç: Obez ve İD olan grupta hematolojik inflamatuar parametreleri ve NLO, MHO ve Sİİ gibi sistemik kronik inflamasyonu gösteren oranları yüksek bulduk. Çalışmamızın artmış yağ dokusunun neden olduğu inflamasyon ve obezlerde İD gelişimi arasındaki ilişkiyi gösterdiğini, gelecekte bu konuda yapılacak çalışmaların erken teşhis ve tedavilerin tasarlanmasında yardımcı olacağını düşünüyoruz

Anahtar Kelimeler:

Obezite, İnsülin resistansı, İnflamasyon, Kan grubu.

Hematological and Inflammatory Parameters Effective on Inflammation and Insulin Resistance in Obesity

Objective: Obesity is one of the predominant risk factors associated with insulin resistance (IR), type 2 diabetes, and many metabolic syndromes. In this study, we aimed to investigate inflammatory parameters and their relationship with IR and blood groups in obese individuals. Materials and Methods: The demographic characteristics, body mass index (BMI), biochemical parameters, hemogram values, and blood group types of individuals in the obesity and control groups were recorded and compared. Results: The mean age was 37.37±11.43 years in obese individuals and 41.8% (n=77) of them had IR. Neutrophil and monocyte counts of the obese individuals with IR were significantly higher than those of the individuals without IR in the control and the obesity groups (p<0.001). The neutrophil/lymphocyte ratio (NLR), the monocyte/high-density lipoprotein cholesterol ratio (MHR), and the systemic immune-inflammation index (SII) were significantly higher in obese individuals with IR compared to obese individuals without IR. IR was more common and neutrophil ratios were significantly higher in obese individuals with B blood type compared to those with O blood type (p=0.023). Conclusion: We found that the values of hematological inflammatory parameters and the levels of NLR, MHR, and SII as indicators of systemic chronic inflammation were increased in obese individuals with IR. We think that our study shows the relationship between inflammation due to excess adipose tissue and the development of IR in obese individuals. We are of the opinion that future studies investigating this subject will help to develop processes for early diagnosis and treatment.

Keywords:

Obesity, Insulin resistance, Inflammation, Blood groups.,

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