Uğur LÖK, Umut GÜLAÇTI, Hüseyin KAFADAR, Hakan KAYA

CRP/Albumin Değerinin Koronavirüs-19 Hastalarının Hastanede Yatış Süresi ve Hastanede Kalış Süresi Üzerindeki Klinik Önemi: Prospektif Çalışma Çalışma

Amaç: İlk tanısı acil servis te yapılan Koronavirüs 2019 (COVID-19) hastalarda C- reaktif protein/albümin oranının (CAR) tanısal ve prognostik önemini araştırması. Gereç ve Yöntemler: Burada sunduğumuz çalışma, tek merkezli, ileriye dönük gözlemsel bir çalışmadır. Çalışmaya toplam 745 katılımcı (385 hasta, 360 kişi) dâhil edildi. CAR, C-reaktif protein (CRP; mg/L) değerinin albümin değerine (gr) bölünmesiyle hesaplandı. Veriler MedCalc İstatistik Yazılımı v12.7.0.0 (Oostende, Belçika) ve Student t testi, ki kare testi ve Pearson korelasyon katsayısı kullanılarak analiz edildi. p<0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Toplam 355 hasta yatarak tedavi edildi ve bunların 30’u ayaktan takip edildi. Hastanede yatan hastaların ve ayaktan hastaların ortalama CAR değerleri sırasıyla 0.34±0.89 ve 0.39±0.72 idi (%95 güven aralığı [GA]: -0.31 ila 0.40; p = 0.796). 309 hasta koğuşlarda, 46 hasta ise yoğun bakım ünitelerinde tedavi edilirken; ortalama CAR değerleri sırasıyla 0.33±0.92 ve 0.44±0.74 idi (%95 GA: -0.17 ila 0.39; p=0.449). CAR değeri arttıkça hastanede kalış süresi de arttı (p< 0,0001). COVID-19 teşhisi için en iyi kesme noktasında CAR’ın %82.66 özgüllük, %69.72 duyarlılık, 4.02 pozitif olasılık ve 0.37 negatif olasılığa sahip olduğu gösterildi. Sonuç: Çalışmadaki COVID-19 hastalarının hastanede kalış süresi, ilk acil servise başvuru anında tespit edilen CAR değerleri ile yakından ilişkiliydi.rının hastanede kalış süresi, ilk acil servise başvuru anında tespit edilen CAR değerleri ile yakından ilişkiliydi.

Anahtar Kelimeler:

Coronavirus disease 2019, C reactive protein to albumin ratio, first admission, hospital stay, Coronavirüs hastalığı 2019, C-reaktif protein/albümin oranı, ilk başvuru, hastanede kalış süresi

Clinical Significance of CRP/Albumin Value on Hospitalization and Length of Hospital Stay of Patients with Coronavirus-19: A Prospective Study

Objective: To investigate the diagnostic and prognostic significance of the C-reactive protein-to-albumin ratio (CAR) in coronavirus disease 2019 (COVID- 19) patients admitted for the first time to a hospital emergency department (ED). Materials and methods: The study we report herein was a single-center, prospective observational study. A total of 745 participants (385 patients, 360 individuals) were included in the study. The CAR was calculated by dividing the C-reactive protein (CRP; mg/L) value by the albumin value (gr). The data were analyzed using MedCalc Statistical Software v12.7.0.0 (Ostend, Belgium) and Student’s t-test, chi square test, and Pearson’s correlation coefficient. A p-value of <0.05was considered statistically significant. Results: A total of 355 patients were hospitalized, and 30 of them were followed as outpatients. The mean CAR values of the hospitalized patients and the outpatients were 0.34±0.89 and 0.39±0.72 respectively (95% confidence interval [CI]: -0.31 to 0.40; p=0.796). A 309 patients were hospitalized in wards and 46, in intensive care units; their mean CAR values were 0.33±0.92 and 0.44±0.74, respectively (95% CI: -0.17 to 0.39; p=0.449). As the CAR value increased, the length of hospital stay also increased (p<0.0001). At the best cut-off point for COVID-19 diagnosis, CAR was shown to have 82.66% specificity, 69.72% sensitivity, 4.02 positive likelihood, and 0.37 negative likelihood. Conclusion: The length of stay in the hospital of the COVID-19 patients in the study was closely related to their CAR values obtained at the time of their first ED admission.s closely related to their CAR values obtained at the time of their first ED admission.

Keywords:

Coronavirus disease 2019, C reactive protein to albumin ratio, first admission, hospital stay,

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