SONGÜL ÇERİBAŞI, MUSTAFA ÖZKARACA, ALİ OSMAN ÇERİBAŞI, Harun ÖZER

T cell lymphoma in An Akkaraman sheep

Teşhis amacıyla Patoloji Anabilim dalına karaciğer ve böbrekleri getirilen 3 yaşında Akkaraman ırkı bir koyunda lenfositik tipte T hücreli lenfoma olgusu tanımlandı. Makroskobik olarak, her iki böbreğin korteksinde, beyaz renkli, yaklaşık 1 cm çapında, nodüler formasyonlar saptandı. Karaciğerde de böbreklerdeki lezyonlara benzeyen düzensiz nodüller mevcuttu. Mikroskobik olarak; karaciğer ve böbrekteki nodüler lezyonların, üniform yapıda lenfosit birikimlerinden oluştuğu gözlendi. Olgun lenfositlere benzeyen ancak boyut olarak daha büyük ve daha az kromatin içeren bu hücreler lenfositik tipte lenfoma hücreleri olarak değerlendirildi. İmmunohistokimyasal olarak tümör hücreleri, CD3 ile pozitif, CD20 ve CD79a ile negatifti. Bundan dolayı, tümör T hücreli lenfositik tipte lenfoma olarak tanımlandı.

Anahtar Kelimeler:

lenfatik hastalıklar, lenfoma, neoplazma, Akkaraman, koyun, T lenfositleri, teşhis, böbrek hastalıkları, böbrekler, lezyon, karaciğer, karaciğer hastalıkları

Bir Akkaraman koyunda T hücreli lenfoma

Lympocytic T cell lymphoma was detected in liver and kidneys of a 3 year old Akkaraman sheep which was submitted to the pathology department for diagnosis. Macroscopically, nodular formations with white colour and about 1 cm size were observed in the cortex of both kidneys. The irregular nodules were observed in the liver, similar to the lesions in the kidneys. Microscopically, the nodular lesions in the liver and kidneys were consisted of uniform lymphocytic accumulations. These lymphocytes were similar to the mature lymphocytes although they were bigger and had less chromatin. Immunohistochemically, tumor cells had positivity with CD3, but negativity with CD20 and CD79a. Thus, the tumor was described as type of lymphocytic T cell lymphoma.

Keywords:

lymphatic diseases, lymphoma, neoplasms, Akkaraman, sheep, T lymphocytes, diagnosis, kidney diseases, kidneys, lesions, liver, liver diseases,

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