Kaveh AZIMZADEH, Keyvan NOURI, Himan FAROOGHI, Sohrab RASOULI, Negar ZAMANI

Plasma malondialdehyde, Thyroid hormones and some blood profiles in ovine Babesiosis

Babeziyozlu koyunlarda bazı kan parametreleri ile birlikte tiroid hormonu ve plazma malondialdehit (MDA) düzeyleri incelendi. Babesia cinsindeki parazitler çiftlik hayvancılığında ekonomik sorunlara neden olurlar. Babesia ile ilgili yayınların çoğu hastalığın komplikasyonlarını ile ilgili olup, kan biyokimyası üzerine yapılan çalışma sayısı azdır. Bu nedenle, Babeziyozlu hayvanlarda kan parametrelerindeki değişikliklerin araştırılması yararlı olabilir. Bu çalışmadaki akut babeziyozlu koyunlar, hastalığa ait klinik belirtileri ve Giemsa ile boyanmış preparatlarda enfekte eritrositleri görerek teşhis edilmiştir. Kan örnekleri, 46 enfekte ve 46 sağlıklı koyunun juguler veninden alınmıştır. Plazmada malondialdehit (MDA), paraoksonaz (PON), LDL, HDL, kolesterol (Chol), toplam plazma protein (TPP), glikoz (GL) ve serumda triiyodotironin(T3) ve tiroksin(T4), eritrosit süperoksit dismutaz (SOD), glutatyon peroksidaz (GSH-Px), katalaz (CAT) ve total antioksidan kapasite (TAK) düzeyleri ölçülmüştür. Sağlıklı grup ile karşılaştırıldığında, enfekte hayvanlarda MDA ve GL düzeylerinde belirgin bir artış ve anti oksidant enzimleri (SOD hariç), TPP, T3, T4, LDL, HDL ve Chol düzeylerinde belirgin bir azalma görülmüştür. Bu sonuçlar hipotiroidizm ile beraber görülen oksidatif stresin, koyun babeziyozunda önemli bir gösterge olduğunu göstermektedir.

Babesiosisli koyunlarda plazma malondialdehid, tiroid hormonları ve bazı kan profilleri

Thyroid hormone and plasma malondialdehyde (MDA) levels as well as other blood parameters were performed in ovine babesiosis. The Babesia genus comprises pathogen parasites that cause economic problems in livestock management. Many published studies have suggested its complications, but few studies have assessed blood biochemistry. Hence, a survey of the changes in blood parameters in animals with babesiosis may be useful. Sheep with acute babesiosis were identified based on clinical signs and the observation of Piroplasms in red blood cells with Giemsa staining of blood smears. Blood samples were obtained from the jugular veins of 46 babesiosis-infected sheep and 46 healthy sheep without babesiosis. Malondialdehyde (MDA), Paraoxonase (PON), low density lipoprotein (LDL), high density lipoprotein (HDL), Cholestrol (Chol), Total plasma protein (TPP) and glucose (GL) in plasma and triiodothyronine (T3), thyroxine (T4) measured in serum. Levels of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and total antioxidant capacity (TAC) were also measured. The results indicated significant increases (P<0.01) in MDA and GL and significant decreases (P<0.01) in the levels of antioxidant enzymes (PON, GSH-Px, CAT, TAC [except SOD], TPP, T3, andT4, LDL, HDL, and Chol levels when compared with healthy group. The results suggested that hypothyroidism with concurrent oxidative stress are significant signs of ovine babesiosis.

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