Protective Eff ects of Chitosan and Chitosan Oligosaccharide on Sodium Fluoride-Induced Testicular Damage in Male Rats: A Stereological and Histopathological Study

The aim of the present study was to investigate the potential protective eff ects of Chitosan (C) and Chitosan Oligosaccharide (COS) on sodium fl uoride (NaF) induced testicular damage. Forty-two male Wistar rats were separated into six groups (n=7). The Control group was given drinking water without Fluoride. NaF group was given NaF (100 mg/L) in their drinking water. NaF+C group was given NaF (100 mg/L) and C (250 mg/kg/day). NaF+COS group was given NaF (100 mg/L) and COS (250 mg/kg/day). C group was given C (250 mg/kg/day). COS group was given COS (250 mg/kg/day). Rats were given C and COS by gastric gavage. As a result, the total number of spermatogonia, Leydig cells, the total volume of the testis, the total volume of germinal epithelium, the total volume of seminiferous tubules, the total length of seminiferous tubules, and the height of germinal epithelium significantly decreased in the NaF group compared to the control group (P

Kitosan ve Kitosan Oligosakkaridin Erkek Sıçanlarda Sodyum Florür Kaynaklı Testis Hasarı Üzerindeki Koruyucu Etkileri: Stereolojik ve Histopatolojik Bir Çalışma

Bu çalışmanın amacı, Kitosan (K) ve Kitosan Oligosakkarit (KOS) sodyum fl orür (NaF) kaynaklı testis hasarı üzerindeki potansiyel koruyucu etkilerini araştırmaktır. Kırk iki erkek Wistar sıçanı altı gruba ayrıldı (n=7). Kontrol grubuna fl orsuz içme suyu verildi. NaF grubuna içme suyunda NaF (100 mg/L) verildi. NaF+K grubuna NaF (100 mg/L) ve K (250 mg/kg/gün) verildi. NaF + KOS grubuna NaF (100 mg/L) ve KOS (250 mg/ kg/gün) verildi. K grubuna K (250 mg/kg/gün) verildi. KOS grubuna KOS verildi (250 mg/kg/gün). Sıçanlara gastrik gavaj ile K ve KOS verildi. NaF grubunda, toplam spermatogonyum sayısı, Leydig hücresi sayısı, toplam testis hacmi, toplam germinal epitel hacmi, toplam seminifer tübül hacmi, seminifer tübüllerin toplam uzunluğu ve germinal epitel yüksekliği kontrol grubuna göre anlamlı olarak azalmıştır (P

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