Molibden ve hayvanlar için enzimsel fonksiyonları

Molibden (Mo), hayvanların dışarıdan almak zorunda olduğu bir iz element olup Mo-kofaktör kompleksinin bir bileşenidir. Mo-kofaktör, Mo ve pterin tarafından oluşturulan organik kompleks bir yapıdır ve Molibdopterin (Mo-pterin) olarak bilinir. Mo-kofaktör vücutta sülfür, nitrojen, karbon siklusları ve temel metabolik reaksiyonları katalize eden ksantin dehidrojenaz/oksidaz, sülfit oksidaz, aldehit oksidaz enzimlerinin yapısında aktif çekirdeği oluşturur. Teorik olarak Mo yetersizliğinde klinik belirti gözlemlenmemekle birlikte noksanlığı durumunda reprodüktif yetersizlik, anemi, özefagus kanseri insidensin de artış, erken yaşta yavru ölümleri ve anoreksi, sinirsel bozukluklar, lens dislokasyonu ve annelerde yüksek mortalite gibi semptomlar bildirilmekle birlikte karakteristik bulgusu yoktur. Mo ve Bakır (Cu) arasında antagonist ilişkiye bağlı olarak Mo noksanlığında Cu toksikasyonu belirtileri, Mo fazlalığında Cu yetersizliği belirtileri mevcuttur. Mo'nin Cu ile etkileşimi gibi S ile olan etkileşimi de önemlidir.

Anahtar Kelimeler:

etkileşim, enzimler, molibden

Molybdenum and enzimatic functions for animals

Molybdenum (Mo) is a essential trace element of animals and it is a component of Molybdenum cofactor complex. Molybdenum cofactor is an organic complex structure which consist of Molybdenum and pterin and referred to as molybdopterin (Mo-pterin). Molybdenum cofactor plays an important role as active centre in Xanthine dehydrogenase/oxidase, Sulfite oxidase and Aldehyde oxidase enzymes which catalyzes the metabolic reactions of sulfur, nitrogen, carbon cycles and basic metabolic reactions in the body. There is no clinical sings in Molybdenum deficiency theoretically. Nevertheless, in case of Molybdenum deficiency, reproductive retardation, anemia, increase in incidence of oesophagal cancer, death at young age, anoreksia, neurological disorders, ocular lens dislocation, high mortality of mother of death new borns were pronounced. But it has no characteristic symptom. There is an antagonistic-action between Mo and Cu. Related to this interrelation, there is Cu toxication symptoms in case of Mo deficency, and there is Cu deficiency symptoms in case of Mo toxication. There is also important interrelation between Mo and S like interrelation between Mo and Cu.

Keywords:

interactions, enzymes, molybdenum,

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